Evidence map›Paper›PMID 40487173›Full record

ArticleMaterials today. Bio2025

Theory-screened Prussian blue analogues-based nanozymes for promoting diabetic wound healing

Qingrong Dong, Xiaomei Shen, Ge Fang, Jia Shi, Xiafeng Zhu, Jiangfeng Du, Hui Zhang, Cuicui Ge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qingrong DongDepartment of Medical Imaging, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Xiaomei ShenCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang, 330022, China.
Ge FangState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, China.
Jia ShiDepartment of Medical Imaging, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Xiafeng ZhuCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang, 330022, China.
Jiangfeng DuDepartment of Medical Imaging, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Hui ZhangDepartment of Medical Imaging, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Cuicui GeState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) induced wound healing impairment remains a serious health problem, which can lead to limb amputation and even shorten life span. Inhibiting ferroptosis of endothelial cells has shown promise in promoting tissue repair and regeneration. However, a majority of known ferroptosis inhibitors belong to either antioxidants or iron-chelators but with poor pharmacological adherence and even serious side effects. Herein, we construct a series of Prussian blue analogues-based nanozymes as ferroptosis nano-inhibitors to simultaneously achieve highly efficient intracellular iron capture and antioxidant properties. Through computational and experimental methods, the optimized Prussian blue analogues (MPBs) with highest iron chelating efficiency and efficacy (CuPBs) are screened out and both the CuPBs and the post-chelated products have been demonstrated to exhibit reactive oxygen species (ROS)-scavenging activities. As expected, the CuPBs successfully inhibit ferroptosis in high glucose-cultured skin repair cells,

Indexed as

Diabetic woundFerroptosis inhibitionIron chelationPrussian blue analogueROS-scavenging activity

Identifiers

PMID40487173
PMCPMC12144524

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.