ArticleAsian journal of pharmaceutical sciences2025
Multifunctional tri-layer wound dressing containing ZNO nanoparticles and IGF-1 as an efficient biomaterial for healing of full thickness skin injuries.
Article in Asian journal of pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Next-generation epidermal patches: Bridging 3D and multidimensional printing for biomedical and personal care innovations.Bioactive materials · 2026Review
- Biomaterials-mediated sequential drug delivery: Emerging trends for wound healing.Asian journal of pharmaceutical sciences · 2025Review
- Article
- 3D printed antibacterial and anti-inflammatory scaffold containing vanillin-loaded Soluplus nanomicelles for healing of infected wounds.Scientific reports · 2025Article
- Multifunctional nanogel dressings with dual acid and HMaterials today. Bio · 2025Article
- "Double-sided protector" Janus hydrogels for skin and mucosal wound repair: applications, mechanisms, and prospects.Journal of nanobiotechnology · 2025Review
- Synergistic effects of zinc oxide and ellagic acid on macrophage infiltration, angiogenesis, and collagen deposition in excisional wounds healing.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mimicking the hierarchical structure of the skin is one of the most important strategies in skin tissue engineering. Monolayer wound dressings are usually not able to provide several functions at the same time and cannot meet all clinical needs. In order to maximize therapeutic efficiency, herein, we fabricated a Tri-layer wound dressing, where the middle layer was fabricated via 3D-printing and composed of alginate, tragacanth and zinc oxide nanoparticles (ZnO NPs). Both upper and bottom layers were constructed using electrospinning technique; the upper layer was made of hydrophobic polycaprolactone to mimic epidermis, while the bottom layer consisted of Soluplus® and insulin-like growth factor-1 (IGF-1) to promote cell behavior. Swelling, water vapor permeability and tensile properties of the dressings were evaluated and the Tri-layer dressing exhibited impressive antibacterial activity and cell stimulation following by the release of ZnO NPs and IGF-1. Additionally, the Tri-layer dressing led to faster healing of full-thickness wound in rat model compared to monolayer and Bilayer dressings. Overall, the evidence confirmed that the Tri-layer wound dressing is extremely effective for full-thickness wound healing.
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