SynthesisPeerJ2025
Associations of the volume and proportion of vigorous-intensity physical activity with all-cause, cardiovascular, and cancer mortality: a systematic review and meta-analysis.
Synthesis in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Measuring long-term physical activity in patients with heart failure and its relation to health-related outcomes.ESC heart failure · 2026Observational
- Predictors of sedentary behaviour in adults: the role of social media addiction and physical activity - a cross-sectional study from Turkey.Journal of global health · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to systematically investigate the associations of varying volumes of vigorous-intensity physical activity (VPA) and its proportion to moderate-to-vigorous intensity physical activity (MVPA) with all-cause, cardiovascular disease (CVD), and cancer mortality. Methods: The review was registered in the PROSPERO (CRD42024525067). Web of Science, Embase, and PubMed were searched from inception to March 22, 2024. Empirical studies that investigated the effects of VPA compared to light-to-moderate intensity physical activities (LMPA) on all-cause, CVD, and cancer mortality were included. Additionally, studies that reported the effects of the proportion of VPA (relative to MVPA) on these mortality risks were also included. Results: In total, 20 studies were included in the analyses. A curvilinear inverse dose-response relationship was observed between the volume of VPA and all-cause, CVD, and cancer mortality. Engaging in 180 minutes of VPA per week was associated with a substantial reduction in mortality risk: 22% for all-cause mortality, 23% for CVD mortality, and 14% for cancer mortality, compared to LMPA. Further increases in VPA volume yielded only modest additional benefits. Furthermore, a U-shaped inverse dose-response relationship was observed between the proportion of VPA (relative to MVPA) and all-cause as well as CVD mortality. Compared to 0% VPA, a 37.5% VPA (relative to MVPA) was associated with the greatest reduction in all-cause mortality (HR = 0.90, 95% CI [0.88-0.93]) and CVD mortality (HR = 0.88, 95% CI [0.83-0.94]) risk, and the size of the reduction remained stable when VPA constituted 30-60% of MVPA. Conclusion: Engaging in more than 180 minutes of VPA per week is associated with a substantial reduction in risks of all-cause, CVD, and cancer mortality. Maintaining VPA at 30-60% of total MVPA appears to be associated with maximal reduction in all-cause and CVD mortality risks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.