Interferon-gamma and interleukin-10 genetic polymorphisms among the pulmonary tuberculosis caused by Malaysia-specific

Nik Mohd Noor Nik Zuraina, Nur Annisa Nasuha Mohd Sedi, Mohammed Dauda Goni, Suharni Mohamad, Mohd Nor Norazmi, Siti Suraiya

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Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Nik Mohd Noor Nik ZurainaDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.ORCID 0000-0002-0009-2772

Nur Annisa Nasuha Mohd SediDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Mohammed Dauda GoniDepartment of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Kota Bharu, Kelantan, Malaysia.ORCID 0000-0003-1301-5351

Suharni MohamadSchool of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Mohd Nor NorazmiSchool of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.ORCID 0000-0002-2817-6441

Siti SuraiyaDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: This study aimed to investigate the role of IFN-γ (+874) A/T and IL-10 (-1,082) A/G SNPs with tuberculosis (TB) disease susceptibility among patients infected with Results: The results indicated a higher frequency of the IFN-γ (+874) TT and IL-10 (-1,082) AG genotypes among TB patients compared to healthy controls. The IFN-γ (+874) AA and IL-10 (-1,082) AG genotypes were more prevalent among TB patients infected with the SIT745/EAI1-MYS

Indexed as

Interferon-gammaInterleukin-10Mycobacterium tuberculosisPolymorphism, Single NucleotideTuberculosis, PulmonaryAdultCase-Control StudiesCross-Sectional StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansMalaysiaMaleMiddle AgedYoung AdultIL10 protein, humanInterferon-gammaInterleukin-10East-African-Indian (EAI) lineageIFN-γ (+874) A/TIL-10 (−1,082) A/GMycobacterium tuberculosisSingle nucleotide polymorphisms (SNP)SIT745/EAI1-MYS

Identifiers

PMID40487054

DOI10.7717/peerj.19576

PMCPMC12145778

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