ArticleFrontiers in pediatrics2025
Co-detection of respiratory pathogens in children with
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Analysis of the pathogen spectrum and epidemiological characteristics of hospitalized children with pneumonia from 2017 to 2024.BMC infectious diseases · 2026Article
- Associations of Mycoplasma pneumoniae load, co-infections, and macrolide resistance with clinical-laboratory profiles in hospitalized pediatric pneumonia: a targeted next-generation sequencing study of bronchoalveolar lavage fluid.Annals of clinical microbiology and antimicrobials · 2026Article
- The predictive value of the ratio of multi-dimensional inflammatory biomarkers in pediatric diseases from the perspective of pro-inflammatory/anti-inflammatory balance: a systematic review.Translational pediatrics · 2026Review
- Coinfection Patterns ofInternational journal of molecular sciences · 2026Article
- Association of lung ultrasound findings with disease severity inTranslational pediatrics · 2026Article
- Network analysis of Mycoplasma pneumoniae pneumonia and Epstein-Barr virus co-infection.BMC infectious diseases · 2026Article
- Article
- The expression and clinical value ofTranslational pediatrics · 2026Article
- Risk factors affecting severe pneumococcal pneumonia in children: a retrospective study.BMC infectious diseases · 2026Article
- Clinical prediction model of Mycoplasma pneumoniae pneumonia combined with influenza virus infection in pediatric patients in Gansu, China.BMC infectious diseases · 2026Article
- Age-related heterogeneity in diagnosis-coded pediatricFrontiers in public health · 2026Article
- Targeted next-generation sequencing analysis of pathogens and microecology in pediatric lower respiratory tract infections identifies risk factors for severe community-acquired pneumonia.Frontiers in cellular and infection microbiology · 2026Article
- Immunopathogenesis, molecular phenotyping, and host-directed interventions for severe pediatricFrontiers in cellular and infection microbiology · 2026Review
- The impact of the COVID-19 pandemic on the epidemiology, clinical manifestations and molecular characteristics ofFrontiers in immunology · 2026Review
- Influenza A Virus andInternational journal of molecular sciences · 2025Article
- Clinical features of MPP with or without viruses among hospitalized children in 2023, Wenzhou, Zhejiang, China.Italian journal of pediatrics · 2025Article
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Authors and funding
17 authors.
Funding
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Abstract
Objective: To investigate the prevalence and clinical significance of respiratory pathogen co-detection in children diagnosed with Methods: A prospective observational multicenter study was conducted, collecting clinical data from pediatric patients diagnosed with MPP in four hospitals across China from December 1 to December 31, 2023. Targeted next-generation sequencing (tNGS) results and clinical characteristics were analyzed. Participants were divided into mild and severe groups according to disease severity. Severe cases were further subdivided into an MP alone group and a multi-pathogen co-detection group. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive performance of inflammatory biomarkers for multi-pathogen co-detection. Results: A total of 266 children were enrolled. Severe cases had significantly higher C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), lactate dehydrogenase (LDH), D-dimer, interleukin-6 (IL-6), IL-10, and interferon-γ (IFN-γ) levels, as well as longer hospital stays (all Conclusions: Multi-pathogen co-infections substantially influence the severity of pediatric MPP. The findings highlight the diagnostic value of tNGS for identifying co-pathogens and underscore the predictive potential of inflammatory biomarkers (especially IL-6 and IL-10). The integration of tNGS and these biomarkers may facilitate early detection and targeted therapeutic interventions, thereby improving prevention and treatment outcomes in pediatric MPP.
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