ReviewClinical, cosmetic and investigational dentistry2025
Cariostatic Agents: From Silver Diamine Fluoride to Emerging Bioactive Compounds.
Review in Clinical, cosmetic and investigational dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dental Caries in Older Adults: A Narrative Review for Non-Dental Providers.International journal of environmental research and public health · 2026Review
- The Potential ofJournal of clinical medicine · 2026Review
- The Efficacy of Plant Extracts Against Key Food-Borne Pathogens: A Mechanistic, Applications, and Advances.Microorganisms · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cariostatic agents are bioactive compounds that inhibit the progression of dental caries by promoting enamel and dentin remineralization while mitigating dentin hypersensitivity. This review conducted an extensive bibliographic search across specialized databases, including Web of Science, PubMed, Cochrane Library, and Scopus, to present a comprehensive and up-to-date analysis of the clinical applications of cariostatic agents. A critical appraisal of the available scientific evidence was performed to evaluate their efficacy and potential as adjunctive therapeutic strategies in caries management. Among the most well-documented agents, silver diamine fluoride (SDF) demonstrates superior efficacy in arresting active carious lesions and preventing lesion progression. Furthermore, emerging bioactive compounds, such as remineralizing peptides and phytochemicals, have exhibited promising anticariogenic properties, though their long-term clinical effectiveness remains under investigation. This review synthesizes key findings from recent research, underscoring the pivotal role of cariostatic agents in evidence-based caries prevention and management. The results highlight the necessity of integrating these agents into a minimally invasive and patient-centered approach, particularly for high-risk populations, to optimize long-term oral health outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.