Evidence map›Paper›PMID 40486882›Full record

ArticleOncology research2025

Is miR-10a a tumor suppressor that modulates proliferation and invasion in high-grade bladder cancer?

THAINá Rodrigues, PATRíCIA Candido, Feres Camargo Maluf, Poliana ROMãO, Carolina Mie Mioshi, Vanessa Ribeiro GUIMARãES, Juliana Alves DE Camargo, Karina Serafim DA Silva, Gabriel Arantes Dos Santos, Iran Amorim Silva and 5 more

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Article in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

THAINá RodriguesLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
PATRíCIA CandidoLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
Feres Camargo MalufLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
Poliana ROMãOLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
Carolina Mie MioshiLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
Vanessa Ribeiro GUIMARãESLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
Juliana Alves DE CamargoLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
Karina Serafim DA SilvaLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
Gabriel Arantes Dos SantosLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
Iran Amorim SilvaLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
Katia Ramos Moreira LeiteLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
William C NahasUro-Oncology Group, Urology Department, University of São Paulo Medical School and Institute of Cancer Estate of São Paulo (ICESP), São Paulo, 01246-000, Brazil.
Sabrina T ReisLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
Ruan PimentaLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.
Nayara Izabel VianaLaboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, 01246-903, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Bladder Cancer (BC) is one of the most commonly diagnosed malignancies worldwide, with high rates of mortality and morbidity. It can be classified as non-muscle invasive bladder cancer (NMIBC) or muscle-invasive bladder cancer (MIBC), with radical cystectomy being the treatment for MIBC, which significantly reduces quality of life. MicroRNAs (miRs) act as critical genetic regulators, with both oncogenic and tumor-suppressive roles. MiR-10a is described as a tumor suppressor in various neoplasms, but its role in BC is controversial. This study aims to assess the activity of miR-10a in cellular invasion and proliferation in two distinct BC cell lines. Methods: The study used high-grade T24 and low-grade RT4 bladder cell lines. Cells were transfected with miR-10a mimic or a non-targeting control. Transfection efficiency was validated by qPCR. Cell proliferation was cultured for 10-14 days. Cell migration and invasion were evaluated using Matrigel. All assays were conducted in triplicate. Results: The T24 cells transfected with miR-10a presented decreased cellular proliferation and invasion compared to the Scramble (

Indexed as

Genes, Tumor SuppressorMicroRNAsUrinary Bladder NeoplasmsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansNeoplasm GradingNeoplasm InvasivenessMicroRNAsMIRN10 microRNA, humanBladder cancer (BC)Cell proliferationMiR-10aTumor suppressor genes

Identifiers

PMID40486882
PMCPMC12144657

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.