Evidence map›Paper›PMID 40486867›Full record

ReviewOncology research2025

Cell cycle proteins: Linking the cell cycle to tumors.

Jie Zhong, Jue Liu, Xing Tang, Wenchao Zhou, Guangming Song, Yuhuan Zeng, Xiaodi Zhang, Jianbin Zhou, JieZhou, L U Cao and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jie ZhongDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Jue LiuDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Xing TangDepartment of Assisted Reproductive Centre, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, 412000, China.
Wenchao ZhouDepartment of Assisted Reproductive Centre, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, 412000, China.
Guangming SongDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Yuhuan ZengDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Xiaodi ZhangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Jianbin ZhouDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China.
JieZhou
L U CaoDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Qunfeng ZhangDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Yukun LiDepartment of Assisted Reproductive Centre, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, 412000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cell cycle is a tightly coupled series of events that enable cells to grow and proliferate. Cyclin-dependent kinases (CDKs) play crucial roles in the cell cycle by enabling cells to transition between different phases when they are activated. Cell cycle proteins enhance the activity of CDKs, while natural CDK inhibitors (CDKIs) suppress them. The cell cycle continues in cycles under normal conditions, but when conditions change, cells halt or terminate the cell cycle. Tumors are tissues that grow out of control, and the mechanisms of various types of tumors are different; however, almost all tumor cells share several common characteristics, including proliferation, prevention of apoptosis and genomic instability. Cellular division is essential in the progression of cancer. A key characteristic of cancer is the uncontrolled growth of tumor cells, which is due to the erratic behavior of several proteins during the cell cycle. Therefore, cell cycle regulators are considered attractive targets for the treatment of cancer. The present analysis highlights proteins that play a direct role in controlling the tumor cell cycle, such as CDKs, and provides a brief overview of checkpoint kinases. The present review also discusses how cell cycle proteins contribute to cancer and describes some of the antitumor drugs that are being researched.

Indexed as

Cell CycleCell Cycle ProteinsNeoplasmsAnimalsAntineoplastic AgentsCyclin-Dependent KinasesHumansAntineoplastic AgentsCell Cycle ProteinsCyclin-Dependent KinasesCell cycleCell cycle checkpointCyclinCyclin dependent kinaseTumors

Identifiers

PMID40486867
PMCPMC12144634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.