Evidence map›Paper›PMID 40486855›Full record

ArticleActa pharmaceutica Sinica. B2025

Acteoside ameliorates hepatocyte ferroptosis and hepatic ischemia-reperfusion injury

Kexin Jia, Yinhao Zhang, Fanghong Li, Runping Liu, Jianzhi Wu, Jiaorong Qu, Ranyi Luo, Zixi Huang, Zhe Xu, Xiaojiaoyang Li

Abstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. [The role of hepatocyte programmed cell death in liver fibrosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Involvement of HMGB1-mediated ferroptosis in systemic diseases.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kexin JiaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Yinhao ZhangSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Fanghong LiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Runping LiuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Jianzhi WuSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Jiaorong QuSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Ranyi LuoSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Zixi HuangSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Zhe XuSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.
Xiaojiaoyang LiSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic ischemia-reperfusion injury (HIRI) has been considered as an inevitable process of liver transplantation. Hepatocyte ferroptosis is a key factor in HIRI development, yet precise mechanism and potential therapies are still unclear. Here, we demonstrated a strong correlation between hepatocyte ferroptosis and the downregulation of poly(rC)-binding protein (PCBP2), which compromised the stability of antiporter system Xc

Indexed as

ActeosideFerroptosisHepatic ischemia–reperfusion injuryHMGB1Macrophage polarizationPCBP2System Xc–

Identifiers

PMID40486855
PMCPMC12138084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.