ArticleFrontiers in cardiovascular medicine2025
Pre-procedural abnormal von Willebrand factor function predicts clinical outcomes after Transcatheter Aortic Valve Implantation: a prospective cohort study.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Total Thrombus-Formation Analysis System (T-TAS) in Aortopathies: A Conceptual and Potential Framework to Spatial Heterogeneity and Regional Context.International journal of molecular sciences · 2026Review
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Authors and funding
13 authors.
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Abstract
Background and objectives: Transcatheter Aortic Valve Implantation (TAVI) is a minimally invasive intervention for aortic stenosis, which is associated with the potential for major vascular complications and arrhythmias. This study aims to identify primary predictors of these complications, emphasizing the roles of Decreased Platelet Count (DPC) and Acquired Von Willebrand Syndrome (AVWS). Methods: We performed a prospective study with 80 patients planning to receive TAVI at the Heart Center, Kaplan Medical Center, Rehovot, Israel. Pre-procedural evaluations include the measurement of baseline platelet counts and the functionality of the von Willebrand factor. The DPC was determined as the percentage decreased from baseline to the lowest count. AVWS was diagnosed through the assessment of von Willebrand factor activity and antigen concentrations. Results: Our results demonstrate that both DPC and AVWS are crucial predictors of major vascular complications. Specifically, patients with a DPC exceeding 20% exhibited a coefficient (Coef) of 1.276 ( Conclusions: Assessing both DPC and von Willebrand factor function is crucial for predicting post-TAVI complications.
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