Evidence map›Paper›PMID 40486732›Full record

ArticleFrontiers in neuroscience2025

APOE genetic variability in an Egyptian cohort of PD.

Eman M Khedr, Martina B William, Aliaa A Elhosseiny, Ali Shalash, Gharib Fawi, Mohamed H Yousef, Shaimaa El-Jaafary, Hamin Lee, Alina Jama, Mohamed Koraym and 23 more

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In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Alzheimer's & dementia (New York, N. Y.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Eman M KhedrDepartment of Neurology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Martina B WilliamInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Aliaa A ElhosseinyInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Ali ShalashDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Gharib FawiDepartment of Neurology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Mohamed H YousefInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Shaimaa El-JaafaryDepartment of Neurology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Hamin LeeDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom.
Alina JamaDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom.
Mohamed KoraymDepartment of Neurology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Asmaa HelmyDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Yara SalahDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Peter GeorgeDepartment of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Nourelhoda A HaridyDepartment of Neurology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Samir NabhanInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Agsha AtputhavadivelDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom.
Sara ElfarrashDepartment of Medical Physiology, Faculty of Medicine, Mansoura University, Dakahleya, Egypt.
Gaafar RagabDepartment of Internal Medicine, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mohamed Tharwat HegazyDepartment of Internal Medicine, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt.
Yasmin ElsaidDepartment of Neurology, Faculty of Medicine, Mansoura University, Dakahleya, Egypt.
Asmaa S GabrInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Nourhan SheblInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Lobna AlyDepartment of Neurology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Nesreen AbdelwahhabDepartment of Neurology, Faculty of Medicine, Mansoura University, Dakahleya, Egypt.
Tamer M BelalDepartment of Neurology, Faculty of Medicine, Mansoura University, Dakahleya, Egypt.
Nehal A B ElsayedDepartment of Neurology, Mansoura International Hospital, Dakahleya, Egypt.
Mohamed El-GamalForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Dakahleya, Egypt.
Shimaa ElgamalDepartment of Neuropsychiatry, Faculty of Medicine, Kafr El Sheikh University, Egypt.
Salma RagabDepartment of Neuropsychiatry, Faculty of Medicine, Kafr El Sheikh University, Egypt.
Jaidaa MekkyDepartment of Neurology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Henry HouldenDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom.
Mie RizigDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom.
Mohamed SalamaInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The apolipoprotein E (APOE) gene, encompassing three alleles (ε2, ε3, ε4), is a critical player in lipid metabolism and has been extensively studied for its role in neurodegenerative diseases. This study examines APOE genetic variability and its association with PD in an Egyptian cohort. Methods: A total of 891 participants, including 422 PD patients and 469 healthy controls, were included in this study. APOE genotyping was performed using Kompetitive Allele Specific PCR (KASP) to detect the rs429358 and rs7412 SNPs, which define the APOE alleles. APOE alleles were categorized based on the genotypes into ε2, ε3, and ε4 groups. Clinical assessments of PD patients included age at onset, disease severity (MDS-UPDRS), and demographic factors. Statistical analyses compared APOE distributions between PD and control groups and examined associations with clinical variables. Results: The ε3 allele was the most prevalent in the cohort (77.3%), aligning with global and African trends. The ε2 allele was observed in 11.4%, and the ε4 allele in 11.3%, with both frequencies being lower than reported African estimates. The ε3/ε3 genotype was predominant in both PD patients (72.51%) and controls (72.07%). The ε4/ε4 genotype was absent in PD cases and rare among controls (0.64%). No significant association was found between APOE genotypes and PD risk, age at onset, or disease severity. Conclusion: Our findings do not support a significant role for APOE in PD susceptibility or severity in Egyptians.

Indexed as

APOEEgyptiangeneticsKASPParkinson’s disease

Identifiers

PMID40486732
PMCPMC12141286

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