ReviewAnnals of medicine and surgery (2012)2025
Anemia and cerebrovascular disease: pathophysiological insights and clinical implications.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hematological parameters of bronchopulmonary dysplasia in preterm infants: a meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Association Between Hemoglobin Levels and Hemorrhagic Stroke Severity and In-Hospital Outcomes: A Multi-Centre Cross-Sectional Study on Recovery and Prognosis in Pakistan.Brain and behavior · 2026Article
- Impact of Iron Supplementation on Clinical Outcomes in Iron-Deficient Heart Failure Patients: A Retrospective Cohort Study in Oman.Journal of clinical medicine · 2026Article
- Observational
- Innovative hematological strategies to combat maternal and child mortality in Africa: focus on anemia and sickle cell disease.Annals of medicine and surgery (2012) · 2026Review
- Coagulation abnormalities in pediatric anemia clinical and laboratory correlates for risk stratification and risk assessment.Annals of medicine and surgery (2012) · 2026Review
- Mediating effects of physical activity, BMI, and dietary iron intake on the relationship between depression and chronic headaches.Scientific reports · 2025Article
- The non-linear association between serum iron and severe impairment of activities of daily living in ischemic stroke patients.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anemia and cerebrovascular disease (CVD) are interconnected conditions that significantly impact global health, often coexisting to worsen clinical outcomes. Anemia-induced hypoxia increases the production of reactive oxygen species (ROS) via mitochondrial dysfunction and xanthine oxidase activity, amplifying oxidative stress. ROS directly harm endothelial cells by disrupting tight junctions, increasing vascular permeability, and compromising the integrity of the blood-brain barrier. This review delves into the pathophysiology of anemia in the context of CVD, emphasizing the impact of hypoxia, oxidative stress, and endothelial dysfunction. Clinically, anemia worsens CVD prognosis by elevating the risk of ischemic and hemorrhagic strokes, delaying recovery, and increasing mortality rates. If untreated, anemia exacerbates neuronal damage, promotes vascular remodeling, and perpetuates systemic inflammation, leading to poor functional outcomes. This review underscores the necessity of timely anemia diagnosis and targeted management in patients with cerebrovascular disease to mitigate these adverse outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.