ReviewAnnals of medicine and surgery (2012)2025
Iron homeostasis and health: understanding its role beyond blood health - a narrative review.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Iron dysregulation in the central nervous system: implications for autism spectrum disorder.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Iron and Other Metal Ions in Human Health and Disease.MedComm · 2026Review
- Association Between Iron Availability and Accelerated Biological Aging in Non-Anemic Women of Reproductive Age: A Nationally Representative Cross-Sectional Study.Biological trace element research · 2026Article
- Maize Biofortification Approaches for Fighting Malnutrition in Sub-Saharan Africa.Plant-environment interactions (Hoboken, N.J.) · 2026Review
- Article
- Evaluation of dietary iron exposure across iron compounds and fortification levels in Saudi Arabia: simulation modeling study.BMC nutrition · 2026Article
- Ferroptosis as a Therapeutic Vulnerability to Overcome Chemoresistance in Gastric Cancer.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Europium-decorated carbon quantum dots for dual CuScientific reports · 2026Article
- Bacterial Adaptive Responses to Green and Chemically Synthesized Silver Nanoparticles: Implications for Resistance Development.Nanomaterials (Basel, Switzerland) · 2026Article
- The Association Between Alopecia Areata and Iron Deficiency Anemia: A Large-Scale Population-Based Case-Control Study.Journal of personalized medicine · 2026Article
- Metal ions in aging and ocular diseases: biology, pathophysiology, and therapeutic strategies.npj aging · 2026Review
- Nutraceutical Interventions in Stunting: Advances, Challenges, and Prospects.Food science & nutrition · 2026Review
- Ferroptosis as a Pathogenic Mechanism and Therapeutic Target in Autoimmune and Inflammatory Skin Diseases.Clinical reviews in allergy & immunology · 2026Review
- Diagnostic utility of serum ferritin in culture proven bacterial infection: an observational study.BMC infectious diseases · 2026Observational
- Prognostic significance of serum iron panel in breast carcinoma: correlation with histopathological grading and molecular immunophenotypes.Discover oncology · 2026Review
- Iron Deficiency Diagnosis in Sub-Saharan Africa: Challenges, Barriers, and Opportunities.Anemia · 2026Review
- Innovative hematological strategies to combat maternal and child mortality in Africa: focus on anemia and sickle cell disease.Annals of medicine and surgery (2012) · 2026Review
- Article
- A DGA-aligned pulse-protein diet may support iron homeostasis in older adults: an exploratory analysis of the PRODMED1 trial.Frontiers in nutrition · 2026Article
- Inflammation and iron metabolism dysregulation as hallmarks of COVID-19 severity.Frontiers in immunology · 2026Observational
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron is an essential trace element that plays a critical role in numerous physiological processes, including oxygen transport, cellular metabolism, immune function, and organ health. While its most well-known function is in hemoglobin synthesis for blood health, iron's regulatory mechanisms extend far beyond the bloodstream. This review examines the broader implications of iron homeostasis, focusing on its impact on cellular functions, immune responses, and the health of organs such as the liver, heart, and brain. Disruptions in iron regulation, including both deficiency and overload, can lead to various disorders, including anemia, iron overload diseases, and chronic inflammation. Iron homeostasis is maintained by a complex balance of absorption, storage, and recycling, primarily regulated by hepcidin, a liver-derived hormone. Inadequate iron levels can impair mitochondrial function, DNA synthesis, and immune cell activation, leading to fatigue, anemia, and a weakened immune system. Conversely, excess iron can promote oxidative stress, contributing to tissue damage and conditions like hemochromatosis, cardiomyopathy, and neurodegenerative diseases. The liver, kidneys, heart, and brain are particularly sensitive to changes in iron balance, which can exacerbate or precipitate various health complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.