ArticleAnnals of medicine and surgery (2012)2025
The prevalence of gastric reflux symptoms in Saudi Arabian statin-users, and associated factors: a tertiary-center cross-sectional observational study.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/aim: Statin medications (hydroxymethylglutaryl-CoA reductase inhibitors) are the agents most commonly used to lower lipids in people with dyslipidemia but are well known to exert unfavorable side effects such as myalgia, which may result in medication discontinuation. In this study, we aimed to assess the relationship between statin use and the development of gastric acid reflux symptoms. Methods: An analytical cross-sectional study was conducted between October 2022 and December 2023 at King Saud University Medical City in Riyadh, Saudi Arabia, among individuals diagnosed with dyslipidemia who had used statin medications regularly for a minimum of 3 months. A simple random sampling technique was utilized. Patients were asked for demographic information, statin type, dose, duration, past medical history, and gastroesophageal reflux symptoms using the Ar-GerdQ tool. Results: A total of 386 participants enrolled in our study. Participants' mean age and standard deviation was 55.4 ± 13.4 years, and the most used statin medication was atorvastatin (69.9%). The total mean GerdQ score was 6.40 (standard deviation 1.90), whereas only 11.4% of participants had gastric reflux symptoms. Different statin types, intensity, and duration were not statistically significantly correlated with gastric reflux symptoms (all Conclusion: Statin medications were not associated with gastroesophageal symptoms, regardless of the statin type, dose, or intensity. Multicenter studies on a national level are warranted to affirm this conclusion further.
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