ReviewAnnals of medicine and surgery (2012)2025
Liquid biopsies for early detection and monitoring of cancer: advances, challenges, and future directions.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Pragmatic Clinical Trial Assessing Response to Neoadjuvant Docetaxel and Trastuzumab in Nigerian Women With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer (ARETTA).JCO global oncology · 2026Trial
- Artificial intelligence in biomarker discovery for diseases: diagnostic and therapeutic prospects.Signal transduction and targeted therapy · 2026Review
- [Applications and limitations of liquid biopsy : Applications and methodological limitations of cell-free DNA analysis in tumor diagnostics].Pathologie (Heidelberg, Germany) · 2026Review
- Autophagy-Circulating Tumor DNA Axis in Molecular Cancer Research: Emerging Mechanisms, Therapeutic Targeting, and Translational Opportunities.International journal of molecular sciences · 2026Review
- Molecular and Immune Mechanisms Governing Cancer Metastasis, Including Dormancy, Microenvironmental Niches, and Tumor-Specific Programs.International journal of molecular sciences · 2026Review
- Integrating single-cell and spatial multi-omics for precision oncology: from tumor ecosystems to clinical decision-making.Frontiers in oncology · 2026Review
- Liquid biopsy in cancer drug resistance: real-time monitoring, mechanistic insights, and translational applications.Frontiers in immunology · 2026Review
- Early multi-cancer detection using liquid biopsy: emerging biomarkers and clinical strategies.Frontiers in oncology · 2026Review
- Beyond single biomarkers: multi-omics strategies to predict immunotherapy outcomes in blood cancers.Clinical and experimental medicine · 2025Review
- Multi-Biofluid Approaches for cftDNA and cftRNA Biomarker Detection: Advances in Early Cancer Detection and Monitoring.Current issues in molecular biology · 2025Review
- Implementation of circulating tumor DNA (ctDNA) testing in precision oncology: A four-year experience from a tertiary cancer center in India.The journal of liquid biopsy · 2025Article
- Enhancing detection and monitoring of circulating tumor cells: Integrative approaches in liquid biopsy advances.The journal of liquid biopsy · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The article offers an extensive survey of the progressions, problems, and future trends of liquid biopsies in the early discovery and surveillance of cancer. Liquid biopsies can detect signals associated with cancer by looking at biological fluids like cerebrospinal fluid, blood, or urine, making them a less invasive alternative to traditional tissue biopsies. Methods: The review explores the molecular biology and techniques behind liquid biopsy, including circulating tumor DNA, circulatory tumor cells, and exosomes. It evaluates clinical applications of liquid biopsy across different cancer types, showing their potential for early diagnosis, monitoring disease progression, and therapy response prediction. Results: The article identifies several critical issues with liquid biopsies, including achieving a balance between high sensitivity and specificity, standardizing protocols, addressing technological heterogeneity, and ensuring cost-effectiveness and accessibility. Also, ethical issues about informed consent, data privacy, incidental findings management, and equal testing access have been examined in this context. Conclusion: Finally, this article sheds light on future developments in liquid biopsies, such as enhanced specificity, sensitivity, and integration with artificial intelligence methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.