SynthesisFrontiers in immunology2025
Prognostic value of systemic inflammation response index in patients with glioma: a meta-analysis.
Synthesis in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of systemic inflammatory response index in patients with bladder cancer: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Platelet-to-Albumin Ratio and Clinical Outcomes in IDH-Wildtype Grade 4 Diffuse Glioma.Journal of clinical medicine · 2026Article
- Geography as an Independent Determinant and Immuno-Inflammatory Correlates of Long-Term Oral Cancer Survival: A Population-Based Cohort Study From India.Cancer medicine · 2026Article
- Potential Diagnostic and Prognostic Value of Neutrophil Counts, Neutrophil-Lymphocyte Ratio, Pan-Immunoinflammatory Score, Systemic Immunoinflammatory Index, and Systemic Inflammatory Response Index in Brain Tumors.Diagnostics (Basel, Switzerland) · 2026Article
- Joint association of systemic inflammatory response index and thromboelastography maximum amplitude with the risk of early atherosclerosis in patients with rheumatoid arthritis.Clinical and experimental medicine · 2026Article
- Association between the inflammatory burden index and erectile dysfunction: a cross-sectional study based on NHANES 2001-2004.Journal of health, population, and nutrition · 2025Article
- Development of a clinical prediction model for inflammatory biomarkers and enlarged basal ganglia perivascular spaces using SHAP analysis: feature selection and model interpretation.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The systemic inflammation response index (SIRI) has been investigated for its prognostic relevance in patients with glioma; however, findings remain inconsistent. Therefore, this meta-analysis aimed to clarify the prognostic value of SIRI in glioma. Methods: PubMed, Web of Science, Embase, Cochrane Library, and CNKI were systematically searched through December 28, 2024. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to assess the association between SIRI and glioma prognosis. Results: A total of 10 studies including 1,942 participants were analyzed. Elevated SIRI was significantly associated with poorer overall survival (OS) (HR=1.67, 95% CI=1.46-1.91, p<0.001) and shorter progression-free survival (PFS) (HR=1.80, 95% CI=1.29-2.52, p=0.001). Subgroup analyses indicated that the prognostic value of SIRI for OS and PFS was consistent regardless of sample size, pathological subtype, cutoff value, or type of survival analysis (p<0.05). Sensitivity and publication bias analyses confirmed the robustness of the results. Conclusion: This meta-analysis demonstrates that high SIRI is a significant predictor of OS and PFS in patients with glioma. SIRI may serve as a promising prognostic biomarker in glioma-related clinical practice.
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