Evidence map›Paper›PMID 40486493›Full record

ArticleBiochemistry and biophysics reports2025

A novel small molecule that enhances lysyl hydroxylase 2 activity and matrix mineralization.

Saori Tomiku, Atsushi Kasamatsu, Reo Fukushima, Tomoaki Saito, Ryunosuke Nozaki, Akiko Suganami, Yutaka Tamura, Mitsuo Yamauchi, Katsuhiro Uzawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Saori TomikuDepartment of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan.
Atsushi KasamatsuDepartment of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan.
Reo FukushimaDepartment of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan.
Tomoaki SaitoDepartment of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan.
Ryunosuke NozakiDepartment of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba, Japan.
Akiko SuganamiDepartment of Bioinformatics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yutaka TamuraDepartment of Bioinformatics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Mitsuo YamauchiDepartment of Biomedical Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
Katsuhiro UzawaDepartment of Oral Science, Graduate School of Medicine, Chiba University, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysyl hydroxylase 2 (LH2), encoded by the

Indexed as

Bone mineralizationCollagen cross-linkIn silico docking simulationsLysyl hydroxylase 2Small molecule

Identifiers

PMID40486493
PMCPMC12145838

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.