ArticleCureus2025
Correlation Between Hepatic Waveform Changes on Doppler Ultrasound and Disease Severity in Cirrhotic Patients.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Liver cirrhosis is the terminal stage of chronic liver disease, marked by progressive fibrosis and vascular remodeling that alters hepatic hemodynamics. Doppler ultrasonography enables non-invasive assessment of these changes by analyzing hepatic vein waveform patterns. This study aimed to evaluate the correlation between hepatic vein waveform alterations and cirrhosis severity, as classified by the Child-Pugh score, and to assess the diagnostic performance of waveform analysis in clinical staging. Methodology In this prospective, observational study, 140 patients with clinically or radiologically confirmed cirrhosis underwent Doppler ultrasonography of hepatic veins. Waveform patterns were categorized as triphasic, biphasic, or monophasic and correlated with Child-Pugh classification and other demographic and laboratory parameters. Statistical analyses assessed the strength of these associations and the diagnostic accuracy of waveform classification. Results The cohort included 59.3% males and 40.7% females, with 45% aged 41-60 years. According to Child-Pugh classification, 22.9% of patients were Class A, 25% were Class B, and 52.1% were Class C. Hepatic vein waveforms were monophasic in 38.6%, biphasic in 36.4%, and triphasic in 25% of patients. A statistically significant association was observed between waveform patterns and disease severity (p < 0.001), with 70.4% of monophasic and 68.6% of biphasic waveforms seen in Class C patients, and 57.1% of triphasic waveforms in Class A patients. Waveform changes also correlated significantly with age (p = 0.008). Diagnostic evaluation revealed 100% sensitivity and negative predictive value, along with 52.2% specificity and 69.5% positive predictive value for predicting advanced cirrhosis. Conclusions Hepatic vein waveform analysis via Doppler ultrasonography is a reliable, non-invasive indicator of cirrhosis severity, demonstrating a strong correlation with the Child-Pugh classification. Its high sensitivity and negative predictive value support its utility as a screening tool for advanced disease. Integrating waveform assessment into routine ultrasound protocols offers valuable prognostic insight without additional cost or complexity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.