ArticleCureus2025
Epidermal Growth Factor Receptor (EGFR) Downregulation by Cetuximab in Salivary Duct Carcinoma: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salivary duct carcinoma (SDC) is a high-grade salivary gland cancer with a poor prognosis. Although therapeutic antibodies capable of targeting several proteins expressed in SDC, such as epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), have been developed, the stability of these antigens during recurrence remains unknown. Herein, we report a case of SDC in the submandibular gland wherein EGFR loss was pathologically confirmed after EGFR-targeted therapy. A 53-year-old man with a right submandibular mass underwent primary tumor resection with ipsilateral radical neck dissection and was diagnosed with SDC along with high EGFR and HER2 expression. Multiple pulmonary metastases appeared five months after the surgery, and the patient received 12 cycles of chemotherapy with paclitaxel and cetuximab. Although most metastatic nodules disappeared with the chemotherapy, a single nodule enlarged 15 months after the treatment. The resection of the pulmonary nodule pathologically confirmed the metastasis of SDC, wherein EGFR expression was downregulated. The patient has remained in remission for seven years after pulmonary metastasectomy without any additional treatment. As selective pressures caused by molecule-targeted therapies may downregulate the expression of the corresponding molecules, pathological examination using the latest tissue samples is ideal for elucidating the biological features of recurrent SDC. Our findings provide valuable insights for developing effective strategies for the treatment of cases with SDC recurrence post molecule-targeted therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.