Evidence map›Paper›PMID 40486338›Full record

ArticleCureus2025

A Case of Toxoplasmic Encephalitis in an HIV-Negative Patient With Multiple Cerebral Infarction-Like Findings in the Early Stages.

Ken Sakamoto, Yoshiaki Nakayama, Shuhei Ogami, Yusuke Koizumi, Katsuichi Miyamoto

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In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ken SakamotoDepartment of Neurology, Wakayama Medical University, Wakayama, JPN.
Yoshiaki NakayamaDepartment of Neurology, Wakayama Medical University, Wakayama, JPN.
Shuhei OgamiDepartment of Neurology, Wakayama Medical University, Wakayama, JPN.
Yusuke KoizumiDepartment of Infection Control and Prevention, Wakayama Medical University, Wakayama, JPN.
Katsuichi MiyamotoDepartment of Neurology, Wakayama Medical University, Wakayama, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxoplasmic encephalitis (TE) is an opportunistic infection that typically manifests in immunocompromised individuals, such as those with HIV infection or AIDS. The characteristic imaging finding is a mass-like lesion with ring enhancement. We report a rare case of TE in a patient who was not infected with HIV with atypical imaging features. An 81-year-old woman developed progressive impaired consciousness over several weeks. Initially, the brain MRI revealed multiple lesions resembling cerebral infarctions, which gradually enlarged and increased in number. Subsequently, gadolinium-enhanced MRI showed ring-enhancing mass-like lesions in the pons and left parietal lobe. Blood tests indicated elevated inflammatory markers and a mildly increased

Indexed as

atypical imaging findingsatypical mri findingsimmunocompromised hostnon-hiv-infected patientstoxoplasmic encephalitis

Identifiers

PMID40486338
PMCPMC12140974

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.