Evidence map›Paper›PMID 40486169›Full record

ArticleRSC advances2025

Targeting apoptotic pathways in cancer: design, synthesis, and molecular docking studies of 1,3,5-trisubstituted-1

Ahmed Temirak, Ahmed A F Soliman, Mohamed B Shalaby, Mariam G Eshak, Wagdy K B Khalil, Zahid Shafiq, Nader M Boshta

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmed TemirakChemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre Dokki Giza 12622 Egypt amtemirak@hotmail.com.ORCID https://orcid.org/0000-0003-3862-5359
Ahmed A F SolimanDrug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, National Research Center Giza 12622 Egypt.
Mohamed B ShalabyToxicology Research Department, Research Institute of Medical Entomology (RIME), General Organisation of Teaching Hospitals and Institutes (GOTHI), Ministry of Health and Population (MoHP) Dokki, P. O. Box 12311 Cairo Egypt.
Mariam G EshakDepartment of Cell Biology, National Research Centre 12262 El-Bohouth St. Cairo Egypt.
Wagdy K B KhalilDepartment of Cell Biology, National Research Centre 12262 El-Bohouth St. Cairo Egypt.
Zahid ShafiqInstitute of Chemical Sciences, Bahauddin Zakariya University Multan Pakistan.ORCID https://orcid.org/0000-0003-4088-8297
Nader M BoshtaChemistry Department, Faculty of Science, Menoufia University Shebin El-Koam 32511 Egypt nboshta2@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The search for new anticancer agents targeting apoptotic and autophagic pathways is crucial due to their roles in cellular homeostasis and cancer cell elimination. In this study, we synthesized and evaluated a series of 1,3,5-trisubstituted-1

Identifiers

PMID40486169
PMCPMC12143201

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.