Evidence map›Paper›PMID 40486121›Full record

Trial reportDrug design, development and therapy2025

The Efficacy of Sodium Bicarbonate Ringer's Solution and Lactate Ringer's Solution in Patients Undergoing Long-Term Abdominal Open Surgery: A Multicenter Prospective Randomized Controlled Study.

Susu Zhou, Kai Zhao, Chunmei Liu, Hong Luo, Jun Shi, Chunhong Liu, Xiaoming Li, Fang Gao, Xiangnan Wu, Qin Shen and 3 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Susu ZhouDepartment of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, Anhui, People's Republic of China.
Kai ZhaoDepartment of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, Anhui, People's Republic of China.ORCID 0000-0002-7943-1932
Chunmei LiuDepartment of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, Anhui, People's Republic of China.
Hong LuoDepartment of Anesthesiology, Hefei First People's Hospital, Hefei, Anhui, People's Republic of China.ORCID 0009-0003-2146-5325
Jun ShiDepartment of Anesthesiology, the First Hospital of Anhui University of Science and Technology, Huainan, Anhui, People's Republic of China.
Chunhong LiuDepartment of Anesthesiology, Huainan Chaoyang Hospital, Huainan, Anhui, People's Republic of China.
Xiaoming LiDepartment of Anesthesiology, Affiliated Hospital of West Anhui Health Vocational College, Luan, Anhui, People's Republic of China.
Fang GaoDepartment of Anesthesiology, Bozhou People's Hospital, Bozhou, Anhui, People's Republic of China.
Xiangnan WuDepartment of Anesthesiology, Anqing 116 hospital, Anqing, Anhui, People's Republic of China.
Qin ShenDepartment of Anesthesiology, Huainan Xinhua Hospital, Huainan, Anhui, People's Republic of China.
Wenhua YuanDepartment of Anesthesiology, General Hospital of Benxi iron and Steel Industry Group of Liaoning Health Industry Group, Benxi, Liaoning, People's Republic of China.
Xiaoqing Chai *Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, Anhui, People's Republic of China.
Xin Wei *Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, Anhui, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Sodium bicarbonate Ringer's solution (BRS) is an intravenous fluid that does not rely on hepatic or renal metabolism. It contains bicarbonate ions (HCO Patients and Methods: A multicenter randomized controlled trial was conducted involving 112 patients undergoing open abdominal surgery. Participants were randomly assigned to either the BRS group (n=55) or the lactated Ringer's solution (LRS) group (n=57). The primary outcome was the incidence of postoperative hyperlactacidemia, while secondary outcomes included serum lactate (Lac), pH, base excess (BE), buffered base (BB), bicarbonate (HCO Results: The incidence of hyperlactic acidemia was lower in Group A compared to Group B (9.1% vs 19.3%, Conclusion: Sodium bicarbonate Ringer's solution and lactate Ringer's solution are both safe options for fluid replacement during long-term open abdominal surgeries. There is no significant difference observed in perioperative lactate levels, acid-base balance, or clinical postoperative outcomes between the two solutions.

Indexed as

AbdomenRinger's LactateSodium BicarbonateAcid-Base EquilibriumAdultAgedFemaleHumansLactic AcidMaleMiddle AgedPostoperative ComplicationsProspective StudiesLactic AcidRinger's LactateSodium Bicarbonatelactate levelslactate Ringer’s solutionopen abdominal surgerysodium bicarbonate Ringer’s solution

Identifiers

PMID40486121
PMCPMC12140924

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.