ArticleJHLT open2025
Lack of genetic recovery despite phenotypic recovery - are these the key to understanding remission vs recovery from heart failure? - Genetic analysis of a mouse model of recovery.
Article in JHLT open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Heart failure (HF) remission involves the normalization of cardiac function but is accompanied by a risk of relapse. The key to achieving (complete) recovery may lie in identifying genes that remain persistently dysregulated despite phenotypic normalization. We used a mouse model of non-ischemic HF recovery to identify persistently dysregulated genes in phenotypically recovered myocardium compared to HF. RNA-seq data from male C57BL/6 mice that underwent HF induction followed by phenotypic recovery were analyzed. Differential expression analyses identified 18 persistently altered genes: 17 were upregulated, and 1 was downregulated. Notably, the only downregulated gene was the transferrin receptor gene (
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