Evidence map›Paper›PMID 40486047›Full record

ArticleJBMR plus2025

Association of exercise and race/ethnicity with atypical femur fracture.

Annette L Adams, Margo Sidell, Alec D Gilfillan, Denison S Ryan, Jörg Schilcher, Dennis M Black

Abstract read
In one paragraph

Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The role of income and educational level as risk factors for atypical femur fractures: A Nationwide Danish Case-Cohort Study with Blinded Radiographic Review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Annette L AdamsDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, United States.ORCID https://orcid.org/0000-0001-7338-4808
Margo SidellDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, United States.
Alec D GilfillanDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, United States.
Denison S RyanDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, United States.
Jörg SchilcherDepartment of Biomedical and Clinical Sciences and Department of Orthopaedics, Linköping University, Linköping, Sweden.
Dennis M BlackDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143, United States.

Funding

Pooling International Cohort Studies of Long-Term Bisphosphonate Use and Atypical Femur FracturesR01AR082562 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Annette L Adams, Douglas C Bauer · 2022 to 2026
$5.4M
NIAMS NIH HHS R01 AR082562
6 · The paper itself

Abstract

Atypical femur fractures (AFF) resemble stress fractures. Stress fractures can result from repetitive stresses like weight-bearing exercise and femoral geometry may influence where stress fractures manifest along the bone. Atypical femur fractures risk is demonstrably greater among Asian women compared to Caucasian women, with differences in femoral geometry hypothesized to contribute to elevated risk. Using a previously established cohort of older adult women, all with bisphosphonate (BP) use sometime during the study period (2010-2017) and some with AFF, we linked self-reported information on weekly exercise to enable evaluation of whether the average weekly minutes of exercise differed by race/ethnicity and whether accounting for any differences explains the increased AFF risk seen among Asian women. Data came from the longitudinal electronic health record of Kaiser Permanente Southern California. Atypical femur fractures were identified by expert review and adjudication of femur fracture radiographs. Race/ethnicity was categorized as White, Asian, and Other. Average weekly minutes of exercise were expressed in units of 15-min blocks. Bivariable and multivariable Poisson regression models were used to estimate incidence rate ratios (IRR) and 95% CI for the associations between exercise, race/ethnicity, and AFF. Exercise levels for all three race/ethnicity categories were different from each other at

Indexed as

activity levelsatypical femur fracturesbisphosphonatesfracturesosteoporosis treatmentweight-bearing exercise

Identifiers

PMID40486047
PMCPMC12143469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.