Evidence map›Paper›PMID 40486046›Full record

ArticleJBMR plus2025

Skeletal site-specific variations in myeloid cells: insights from single-cell RNA sequencing of the mandible and femur.

Rachel Clark, Ryan Keesler, Adnan Ali, Marissa Macchietto, Sarah A Munro, Rachel Uppgaard, Elizabeth Bradley, Amy Tasca, Kim Mansky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachel ClarkOral Biology Graduate Program, University of Minnesota School of Dentistry, Minneapolis, MN 55455, United States.
Ryan KeeslerDivision of Orthodontics, Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, United States.
Adnan AliDepartment of Biochemistry, Genetics and Biophysics, University of Minnesota, Minneapolis, MN 55455, United States.
Marissa MacchiettoMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455, United States.
Sarah A MunroMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455, United States.
Rachel UppgaardDivision of Oral Surgery, Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, United States.
Elizabeth BradleyDepartment of Orthopedic Surgery and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, United States.
Amy TascaDivision of Orthodontics, Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, United States.
Kim ManskyDivision of Orthodontics, Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, United States.

Funding

Minnesota Craniofacial and Oral Health Research ExperienceR25DE032529 · NIDCR · UNIVERSITY OF MINNESOTA · PI Kim Carpenter Mansky · 2023 to 2026
$521k
Characterization of mandible derived osteoclasts under physiological and bone healing conditionsF30DE033618 · NIDCR · UNIVERSITY OF MINNESOTA · PI PHILLIPS, RACHEL BLEVINS · 2024 to 2024
$50k
NIDCR NIH HHS F30 DE033618NIDCR NIH HHS R25 DE032529
6 · The paper itself

Abstract

To understand differences that exist between the cell populations in different skeletal sites, we performed an unbiased genetic survey via single-cell RNA sequencing of CD11b+ myeloid cells from mandibular- and femur-derived bone marrow of 2-mo-old C57BL/6 mice. Our results reveal transcriptomic evidence that suggests a uniquely inflammatory genetic profile of the mandibular-derived CD11b+ cells. The monocyte cell population found within the CD11b+ cells analyzed by scRNA-seq expressed

Indexed as

craniofacialinflammationosteoclastssequencingtranscription

Identifiers

PMID40486046
PMCPMC12143482

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.