ArticleJournal of clinical and experimental dentistry2025
A Rare Case of Myofibroma of the Mandible Complicated by Traumatic Neuroma Arising After a Conservative Surgical Approach.
Article in Journal of clinical and experimental dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Myofibroma (MF) is an uncommon benign mesenchymal neoplasm composed of myofibroblasts. Traumatic neuroma (TN) is a non-neoplastic proliferative disorder of the nerve sheath in response to injury or surgery. Both are uncommon in the jaws. We present a case of a 39-year-old Afro-descendant woman with a unilocular radiolucent lesion in the posterior mandible, showing mild expansion and cortical disruption. Biopsy revealed proliferation of fascicularly arranged spindle cells strongly positive for α-SMA and podoplanin, with low Ki-67 (<5%), and the final diagnosis was central MF. Ten months after enucleation and curettage, persistent pain led to a second biopsy, which revealed proliferation of multiple hyperplastic nerve fascicles consistent with TN. The postoperative course was uneventful with 14-month follow-up. A discussion on the clinicopathological criteria for differential diagnosis of MF and other spindle cell tumors as well as the rare occurrence of post-surgical TN is also provided.
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