A comparative study of platelet-rich fibrin plugs versus biphasic calcium phosphate in treating infrabony defects in patients with periodontitis: Insights from a randomized controlled trial.

Background: Bone grafts and growth factors have been utilized to manage infrabony defects. Platelet-rich fibrin (PRF) has demonstrated significant potential due to its sustained release of growth factors and autologous nature. This study aimed to conduct a clinical and radiographic comparison of PRF plug as a sole graft versus biphasic calcium phosphate (BCP) (SybografTM - Plus) in treating infrabony defects in patients with chronic periodontitis. Material and Methods: Forty patients were recruited for this randomized controlled interventional study and assigned to Group A or B via computer randomization. After open flap debridement, the infrabony defects were grafted with a PRF plug in Group A (n=20) and BCP in Group B (n=20). Clinical parameters, including the Plaque Index (PI) and Gingival Index (GI), were measured at baseline, one month, three months, and six months post-surgery while Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL) were measured at baseline, three months, and six months post-surgery. The radiographic depth of defect and bone fill were assessed at baseline, immediately, and six months post-surgery. Parametric tests (t-test for two groups, ANOVA for three or more groups) were employed for statistical analysis. Results: At six months post-surgery, the differences in terms of PI ( Conclusions: PRF plug as a sole grafting material has shown promising results for periodontal regeneration comparable to BCP in the treatment of infrabony defects in patients with chronic periodontitis.