Evidence map›Paper›PMID 40485912›Full record

ArticleJournal of contemporary brachytherapy2025

Virtual reality-guided simulation of brachytherapy: Two case reports.

Kae Okuma, Hiroki Nakayama, Madoka Sakuramachi, Shintaro Kimura, Wakako Yatsuoka, Akane Yoshiba, Koji Inaba, Tomoya Kaneda, Tairo Kashihara, Kana Takahashi and 3 more

Abstract readCase Reports
In one paragraph

Article in Journal of contemporary brachytherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kae OkumaDepartment of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.
Hiroki NakayamaRadiation Safety and Quality Assurance Division, National Cancer Center Hospital, Tsukiji 5-1-1 Chuo-ku, Tokyo 104-0045, Japan.
Madoka SakuramachiDepartment of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.
Shintaro KimuraDepartment of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.
Wakako YatsuokaDepartment of Dentistry, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.
Akane YoshibaDepartment of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.
Koji InabaDepartment of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.
Tomoya KanedaDepartment of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.
Tairo KashiharaDepartment of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.
Kana TakahashiDepartment of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.
Ayaka NagaoDepartment of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.
Yuko NakayamaDepartment of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.
Hiroshi IgakiDepartment of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Brachytherapy requires precise applicator placement, especially in complex cases, where standard imaging may not provide sufficient guidance. Virtual reality (VR) technology has emerged as a valuable tool for pre-simulation, enabling improved anatomical understanding and procedural planning. We reported two cases, in which VR pre-simulation was used to enhance brachytherapy planning in challenging anatomical regions. Cases description: Case 1: A 51-year-old woman with carcinoma of unknown primary and poorly differentiated adenocarcinoma had previously undergone chemotherapy and radiation therapy for a large tumor in the right common iliac region. The tumor recurred and invaded the sacrum, requiring interstitial brachytherapy due to prior radiation dose constraints. Applicator placement was challenging, necessitating collaboration with an interventional radiology (IR) physician. VR pre-simulation facilitated multi-disciplinary communication and optimized puncture, leading to a safer and more accurate procedure. Case 2: A 46-year-old man with floor of the mouth cancer was initially scheduled for total glossectomy and laryngectomy, but opted for radiotherapy after significant tumor shrinkage. To minimize radiation dose to the mandible, interstitial brachytherapy was added. Due to safety concerns regarding prolonged applicator placement, a strategy of daily insertion and removal was adopted. A custom-made mouthpiece with a single guiding applicator was prepared by a dentist, and multiple needle-type applicators were employed. VR pre-simulation enabled precise needle insertion and facilitated procedural consistency, even among radiation oncologists unfamiliar with head and neck brachytherapy. Conclusions: VR technology enhances pre-procedural planning, improve multi-disciplinary coordination, and optimize needle placement in brachytherapy for complex anatomical sites. By integrating VR into brachytherapy workflows, treatment precision and safety can be improved across various anatomical regions.

Indexed as

brachytherapythree-dimensional imagevirtual reality

Identifiers

PMID40485912
PMCPMC12140148

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.