Evidence map›Paper›PMID 40485906›Full record

ArticleEJHaem2025

Final Results of a Phase 2 Multi-Arm Study of Magrolimab Combinations in Patients With Relapsed/Refractory Multiple Myeloma.

Barry Paul, Jiri Minarik, Francesca Cottini, Cristina Gasparetto, Jack Khouri, Mitul Gandhi, Jens Hillengass, Moshe Levy, Michaela Liedtke, Sudhir Manda and 10 more

Registry-linked trialAbstract read
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04892446 (A Phase 2 Multi-Arm Study of Magrolimab Combinations in Patients With Relapsed/Refractory Multiple Myeloma), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04892446 phase2terminatednot on this map

A Phase 2 Multi-Arm Study of Magrolimab Combinations in Patients With Relapsed/Refractory Multiple Myeloma

TypeinterventionalSponsorGilead SciencesRan2021 to 2024Enrolled36ConditionsMultiple MyelomaArmsMagrolimab, Daratumumab, Pomalidomide, Dexamethasone, Bortezomib
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Barry PaulAtrium Health Levine Cancer Institute Wake Forest University School of Medicine Charlotte North Carolina USA.ORCID https://orcid.org/0000-0003-2702-8225
Jiri MinarikFakultni Nemocnice Olomouc Olomouc Czech Republic.
Francesca CottiniThe Ohio State University Columbus Ohio USA.ORCID https://orcid.org/0000-0001-8676-7840
Cristina GasparettoDuke Cancer Institute Durham North Carolina USA.
Jack KhouriCleveland Clinic Cleveland Ohio USA.ORCID https://orcid.org/0000-0002-2473-6528
Mitul GandhiUS Oncology Site, Virginia Cancer Specialists Fairfax Virginia USA.
Jens HillengassRoswell Park Cancer Institute Buffalo New York USA.
Moshe LevyBaylor University Medical Center Dallas Texas USA.
Michaela LiedtkeStanford Cancer Center Palo Alto California USA.
Sudhir MandaArizona Oncology Associates Tucson Arizona USA.
Irwindeep SandhuCross Cancer Institute Edmonton Alberta Canada.
Douglas SborovHuntsman Cancer Institute at the University of Utah Salt Lake City Utah USA.ORCID https://orcid.org/0000-0003-4268-2698
Ivan SpickaCharles University Hospital Kralovske Vinohrady Prague Czech Republic.
Saad UsmaniMemorial Sloan-Kettering Cancer Center New York New York USA.
Mei DongGilead Sciences, Inc Foster City California USA.
Lin GuGilead Sciences, Inc Foster City California USA.
Carmen LeungGilead Sciences, Inc Foster City California USA.
Parul DoshiGilead Sciences, Inc Foster City California USA.
Christine ChenPrincess Margaret Cancer Centre Toronto Ontario Canada.ORCID https://orcid.org/0000-0002-9528-3669
Ludek PourUniversity Hospital Brno Brno Czech Republic.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Investigating CD56 signaling in multiple myeloma growth and immune escapeK08CA263476 · NCI · OHIO STATE UNIVERSITY · PI Francesca Cottini · 2022 to 2026
$1.3M
NCI NIH HHS K08 CA263476NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Introduction: Patients with pretreated relapsed/refractory multiple myeloma (RRMM) have a poor prognosis and limited treatment options, underscoring the need for safe treatments with durable efficacy. Methods: This Phase 2 study evaluated magrolimab (Magro) plus daratumumab (Dara) or pomalidomide/dexamethasone (Pd) or carfilzomib/dexamethasone (Kd) in RRMM. The primary efficacy endpoint was objective response rate (ORR). Results: ORR was 14.3% (Magro+Dara; Conclusion: As the study closed early, insights into the clinical profile of Magro combinations in RRMM are limited. Trial Registration: This trial was registered at www.clinicaltrials.gov as #NCT04892446.

Indexed as

carfilzomibdaratumumabdexamethasonemagrolimabpomalidomiderelapsed/refractory multiple myeloma

Identifiers

PMID40485906
PMCPMC12143418

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.