ReviewCureus2025
Leukocyte-Platelet-Rich Fibrin Combined With Demineralized Bovine Bone Mineral for Maxillary Sinus Augmentation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Characterization and Biological Performance of Anglerfish Collagen and Bovine Collagen.Applied biochemistry and biotechnology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maxillary sinus augmentation is considered the gold standard procedure for increasing bone volume to support dental implant placement. However, the added benefit of leukocyte-platelet-rich fibrin (L-PRF) when combined with deproteinized bovine bone mineral (DBBM) remains uncertain. This systematic review and meta-analysis aimed to evaluate the histomorphometric outcomes of L-PRF combined with DBBM compared to DBBM alone. A comprehensive search of PubMed, Scopus, Web of Science, and Cochrane Central was conducted from inception through May 2025 to identify randomized controlled trials (RCTs) comparing the combination of L-PRF and DBBM versus DBBM alone in patients undergoing lateral maxillary sinus augmentation. Primary outcomes included the percentage of new bone formation and residual bone graft. Secondary outcomes were the percentage of soft tissue and the Implant Stability Quotient (ISQ) at the implant loading stage. Pooled mean differences (MDs) with 95% confidence intervals (CIs) were calculated using a random-effects model. All analyses were performed using STATA MP version 18 (StataCorp LLC, College Station, TX, US). Five RCTs involving 140 patients were included. The combination of L-PRF and DBBM significantly increased new bone formation (MD = 7.07; 95% CI: 2.20 to 11.93; p < 0.001; I² = 36.86%, p = 0.07) and reduced residual graft material (MD = -7.93; 95% CI: -11.20 to -4.66; p < 0.001; I² = 0%, p = 0.91) compared to DBBM alone. In conclusion, the adjunctive use of L-PRF with DBBM enhances histomorphometric outcomes in maxillary sinus augmentation. Further high-quality, long-term RCTs with standardized protocols are needed to confirm these findings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.