Evidence map›Paper›PMID 40485719›Full record

ArticleKidney international reports2025

Longitudinal Lipid Trajectories and Progression of CKD in Children.

Uwe Querfeld, Marietta Kirchner, Francesca Mencarelli, Karolis Azukaitis, Aysun Bayazit, Ali Duzova, Anke Doyon, Nur Canpolat, Ipek Kaplan Bulut, Lukasz Obrycki and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Uwe QuerfeldDepartment of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité University Hospital, Berlin, Germany.
Marietta KirchnerInstitute for Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
Francesca MencarelliPediatric Nephrology Unit, Department of Pediatrics, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Karolis AzukaitisClinic of Pediatrics, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Aysun BayazitDepartment of Pediatric Nephrology, Cukurova University, Adana, Turkey.
Ali DuzovaDivision of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Anke DoyonPediatric Nephrology Division, Department of Pediatrics I, University of Heidelberg, Heidelberg, Germany.
Nur CanpolatDepartment of Pediatric Nephrology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
Ipek Kaplan BulutDivision of Pediatric Nephrology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
Lukasz ObryckiDepartment of Nephrology, Kidney Transplantation and Hypertension, Children's Memorial Health Institute, Warsaw, Poland.
Justine BacchettaPediatric Nephrology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Université de Lyon, Lyon, France.
Rukshana ShroffUCL Great Ormond Street Institute of Child Health, London, UK.
Dusan ParipovicNephrology Department, University Children's Hospital and School of Medicine, University of Belgrade, Serbia.
Cengiz CandanDivision of Pediatric Nephrology, Istanbul Medeniyet University, Göztepe Hospital, Istanbul, Turkey.
Jerome HarambatPediatric Nephrology Unit, Department of Pediatrics, Bordeaux University Hospital, France.
Alev YilmazIstanbul University Istanbul Faculty of Medicine, Istanbul, Turkey.
Harika AlpayDepartment of Pediatric Nephrology, Marmara University Faculty of Medicine, Istanbul, Turkey.
Jun OhPediatric Nephrology, UKE University Children's Hospital, Hamburg, Germany.
Hakan ErdoganDepartment of Pediatric Nephrology, Dörtçelik Children's Hospital, Bursa, Turkey.
Claus P SchmittPediatric Nephrology Division, Department of Pediatrics I, University of Heidelberg, Heidelberg, Germany.
Anette MelkDepartment of Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Franz SchaeferPediatric Nephrology Division, Department of Pediatrics I, University of Heidelberg, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: There are discrepant findings regarding the effect of dyslipidemia on disease progression in adult patients with chronic kidney disease (CKD). Methods: In a prospective cohort study of children with stage 3 to 5 (predialysis) CKD, triglycerides (TGs), total cholesterol (CHOL), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured semiannually. We investigated whether CKD progression is associated with serum lipid levels at baseline and with lipid trajectories during follow-up. CKD progression was defined as the time to a composite event of 50% reduction in estimated glomerular filtration rate (eGFR), eGFR < 10 ml/min per 1.73 m Results: A total of 681 patients aged 12.2 ± 3.3 years with a mean eGFR of 26.9 ± 11.6 ml/min per 1.73 m Conclusions: These data do not support an important role for lipids in the progression of CKD in children.

Indexed as

childrenchronic kidney diseasedyslipidemiaprogressionproteinuria

Identifiers

PMID40485719
PMCPMC12142784

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