Evidence map›Paper›PMID 40485690›Full record

ArticleKidney international reports2025

Persistent B Cell Depletion After Rituximab for Autoimmune and Glomerular Diseases: A Case Series.

Orhan Efe, Gabriel Sauvage, Anushya Jeyabalan, Ayman Al Jurdi, Harish S Seethapathy, Katherine Cosgrove, Frank B Cortazar, Karen A Laliberte, Reza Zonozi, John L Niles

Abstract read
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Orhan EfeVasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Gabriel SauvageVasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Anushya JeyabalanVasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Ayman Al JurdiVasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Harish S SeethapathyVasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Katherine CosgroveVasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Frank B CortazarNew York Nephrology Vasculitis and Glomerular Center, Saint Peter's Hospital-Albany, Albany, New York, USA.
Karen A LaliberteVasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Reza ZonoziNephrology Associates of Northern Virginia, Fairfax, Virginia, USA.
John L NilesVasculitis and Glomerulonephritis Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Persistent B cell depletion is a rare complication of rituximab treatment, and its clinical implications are unknown. Methods: This retrospective case series included patients with glomerular and autoimmune diseases who developed persistent B cell depletion (< 5 CD19 Results: Among 1519 patients who received rituximab, 2% ( Conclusion: Persistent B cell depletion is a rare complication of rituximab treatment, mostly affecting patients with exposure(s) to cytotoxic therapies for recurrent diseases. It is characterized by prolonged disease remission and increased infection risk.

Indexed as

complications of rituximabpersistent B cell depletionprolonged B cell depletionrituximab

Identifiers

PMID40485690
PMCPMC12142800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.