ArticleMovement disorders clinical practice2025
Cardiorespiratory Response to Exercise in Parkinson's Disease: Associations with Autonomic Dysfunction and Physical Activity.
Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Lactate dynamics in Parkinson's disease: striatal circuit vulnerability, biomarker potential, and therapeutic windows.Molecular medicine (Cambridge, Mass.) · 2026Review
- High intensity interval training for Parkinson's disease: A scoping review of systemic effects and physiological adaptations.Journal of Parkinson's disease · 2026Article
- The exercise-microbiota-queuine-tRNA axis in Parkinson's disease: evidence, uncertainties, and experimental priorities.Frontiers in neuroscience · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth autonomic dysfunction and low levels of physical activity could contribute to reduced cardiorespiratory fitness in people with Parkinson's disease (PD). However, the interrelationship between these concepts is not well understood.
objectivesOur aim was to gain more insight into autonomic dysfunction and physical activity in relation to cardiorespiratory fitness in PD.
methodsWe included 59 individuals with PD (37% women, mean age 65.1 years; mean disease duration 4.5 years; Hoehn and Yahr stage 1-3). All participants completed a cardiopulmonary exercise test (CPET). We examined the association between parameters assessed during a CPET (peak oxygen consumption [VO
resultsHigher SCOPA-AUT was associated with lower HR
conclusionsBoth autonomic dysfunction and physical activity are associated with a reduced cardiorespiratory response to exercise in PD, but affected different CPET parameters. Future studies should determine the responsiveness of these CPET parameters to change, in order to implement such parameters as endpoints in clinical trials.
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Registered trials
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