Evidence map›Paper›PMID 40485364›Full record

ArticleJournal of cachexia, sarcopenia and muscle2025

Sarcopenia in Ageing and Chronic Illness: Trial Endpoints and Regulatory Issues.

Stephan von Haehling, Henning T Langer, Steven B Heymsfield, William J Evans, Stefan D Anker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Nutrients · 2026
    Review
  5. Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephan von HaehlingDepartment of Cardiology and Pneumology, University of Göttingen Medical Center, Göttingen, Germany.ORCID 0000-0002-9818-042X
Henning T LangerMuscle Wasting Laboratory, Department for Geriatrics and Medical Gerontology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
Steven B HeymsfieldMetabolism and Body Composition, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
William J EvansDepartment of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California, USA.
Stefan D AnkerBerlin Institute of Health-Center for Regenerative Therapies (BCRT), Charité- Universitätsmedizin Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In December 2024, the Society on Cachexia and Wasting Disorders (SCWD) hosted a Regulatory and Trial Update Workshop in Washington, D.C., bringing together experts from academia, industry, and the US Food and Drug Administration (FDA). This article summarizes key topics discussed during the meeting, including diagnostic challenges, emerging assessment methods, and trial endpoints. The D

Indexed as

AgingSarcopeniaChronic DiseaseClinical Trials as TopicHumansclinical trialsdiagnosticsendpointsmuscle wastingpatient‐reported outcomessarcopeniatreatment

Identifiers

PMID40485364
PMCPMC12146653

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.