ArticleCNS neuroscience & therapeutics2025
Surgical Treatment Could Improve Long-Term Functional Outcomes in Intracerebral Hemorrhage Patients With NIHSS ≥ 10.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
background and purposeSurgical treatment has been shown to decrease mortality in patients with intracerebral hemorrhage (ICH) but has not consistently improved functional outcomes. This study aimed to investigate whether surgical treatment could enhance functional outcomes in ICH patients with a National Institutes of Health Stroke Scale (NIHSS) score of 10 or higher.
methodsThis multicenter study included patients from a registry cohort in China with supratentorial ICH, NIHSS scores of 10 or higher, and hematoma sizes of 25 mL or more. Patients were divided into surgical and medical treatment groups. The primary outcome was a modified Rankin Scale (mRS) score of 0-3 at 1 year.
resultsA total of 429 patients were analyzed. The median NIHSS score at admission was 22 [15-29], and the ICH volume was 50 [35.28-72.9] ml. The surgical group had a higher proportion of mRS scores of 0-3 at 1 year compared to the medical group (49.68% vs. 38.32%, p = 0.022). Both craniotomy and minimally invasive surgery improved functional outcomes at 1 year (mRS 0-3, craniotomy: OR 2.324, 95% CI 1.266-4.267, p = 0.007; minimally invasive surgery: OR 4.884, 95% CI 1.914-12.445, p = 0.001).
conclusionFor patients with supratentorial ICH, NIHSS scores of 10 or higher, and hematoma sizes of 25 mL or more, surgical treatment improved functional outcomes at 1 year compared to medical treatment. The specific subgroup of ICH patients that could benefit from surgical intervention remains controversial.
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