Evidence map›Paper›PMID 40485229›Full record

ArticleInternational journal of stem cells2025

Establishment of a Human Induced Pluripotent Stem Cell-Derived Cerebral Cortex Organoid Model for Neurotoxicity Assessment.

Seohee Park, Chang-Whan Yoon, Haeun Kim, Jiyou Han, Soo Hyun Nam, Kang Pa Lee, Sang-Hyuk Lee, Byung-Ok Choi, Jong Hyun Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Seohee ParkDepartment of Health Science and Technology, Samsung Advanced Institute for Health Sciences & Technology, Seoul, Korea.ORCID https://orcid.org/0009-0008-8597-0917
Chang-Whan YoonDepartment of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0009-0009-5940-3430
Haeun KimDepartment of Health Science and Technology, Samsung Advanced Institute for Health Sciences & Technology, Seoul, Korea.ORCID https://orcid.org/0009-0001-5599-4327
Jiyou HanDepartment of Biomedical and Chemical Sciences, Hyupsung University, Hwasung, Korea.ORCID https://orcid.org/0000-0001-5749-3086
Soo Hyun NamCell & Gene Therapy Institute, Samsung Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0003-4421-1793
Kang Pa LeeResearch & Development Center, UMUST R&D Corporation, Seoul, Korea.ORCID https://orcid.org/0000-0002-6136-4970
Sang-Hyuk LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-4412-3486
Byung-Ok ChoiDepartment of Health Science and Technology, Samsung Advanced Institute for Health Sciences & Technology, Seoul, Korea.ORCID https://orcid.org/0000-0001-5459-1772
Jong Hyun KimDepartment of Biomedical and Chemical Sciences, Hyupsung University, Hwasung, Korea.ORCID https://orcid.org/0009-0003-3130-6301

Funding

NIEHS NIH HHS 27302C0115
6 · The paper itself

Abstract

Human pluripotent stem cell (hPSC)-derived brain organoids have emerged as innovative models for drug screening and cytotoxicity evaluation. However, their inherent cellular heterogeneity presents challenges in isolating targeted neuronal populations, such as upper motor neurons, which are crucial for motor cortex function. In this study, we developed motor cortex-like organoids enriched with excitatory glutamatergic and inhibitory GABAergic neurons to assess neurotoxicity in the upper motor neurons-a key component of voluntary motor control. By optimizing the differentiation protocols, we achieved robust expression of

Indexed as

GABAergic neuronsGlutamatergic systemMotor cortexOrganoids

Identifiers

PMID40485229
PMCPMC12394079

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.