Evidence map›Paper›PMID 40485192›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Metal-Mediated Il-8 Binding to Heparan Sulfate Evaluated by Electrochemical Impedance Spectroscopy.

Ariel Shitrit, Israel Alshanski, Karin Mor, Jörg Rademann, Raghavendra Kikkeri, Mattan Hurevich, Shlomo Yitzchaik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ariel ShitritThe institute of chemistry and Center of Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.ORCID https://orcid.org/0000-0003-1362-7016
Israel AlshanskiThe institute of chemistry and Center of Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.ORCID https://orcid.org/0000-0002-9310-1921
Karin MorThe institute of chemistry and Center of Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
Jörg RademannMedicinal Chemistry, Freie Universität Berlin, Königin-Luise-Strasse 2+4, Berlin, 14195, Germany.ORCID https://orcid.org/0000-0001-6678-3165
Raghavendra KikkeriIndian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune, 411008, India.ORCID https://orcid.org/0000-0002-4451-6338
Mattan HurevichThe institute of chemistry and Center of Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.ORCID https://orcid.org/0000-0002-1038-8104
Shlomo YitzchaikThe institute of chemistry and Center of Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.ORCID https://orcid.org/0000-0001-5021-5139

Funding

European Innovation Council 101046369HORIZON EUROPE Innovative Europe 101046369Israel Ministry of Science 81152Israel Science Foundation 1805/22Ministry of Science and Technology, Israel 81152
6 · The paper itself

Abstract

Heparan sulfate (HS) interactions with interleukin 8 (IL-8) are crucial for immune system response. The structural features of the HS and the environmental entities, such as metal ions, can regulate these interactions. However, it is challenging to evaluate the effect of each parameter on the interactions because of low accessibility to well-defined saccharides and the lack of characteristic features to be determined by analytical tools. We evaluated the effect of the HS structural features on IL-8 binding affinity utilizing electrochemical impedance spectroscopy (EIS) and X-ray photoelectron spectroscopy (XPS). We showed that the metal ions Ca

Indexed as

CalciumHeparan SulfateInterleukin-8MagnesiumDielectric SpectroscopyHumansPhotoelectron SpectroscopyPolysaccharidesProtein BindingCalciumHeparan SulfateInterleukin-8MagnesiumPolysaccharidesEISheparan sulfateinterleukin 8metal ionsX‐ray photoelectron spectroscopy

Identifiers

PMID40485192
PMCPMC12238926

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.