ArticleClinical endocrinology2025
CD105 (Endoglin) Expression as a Prognostic Marker in Aggressive Papillary Thyroid Carcinoma.
Article in Clinical endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Immunohistological parathormone production changes and angiogenesis in normal and adenomatous human parathyroid glands.Histology and histopathology · 2026Article
- Breast cancer stem cell activity driven byWorld journal of stem cells · 2026Article
- Increased HIF-2α and CD105 (endoglin) expression is associated with poor differentiation in pheochromocytomas and paragangliomas.Frontiers in endocrinology · 2026Article
- Construction and validation of risk models of prognostic genes associated with parthanatos in papillary thyroid carcinoma based on bioinformatics.Discover oncology · 2025Article
- Spatial ecostructural modelling of endometrial cancer identifies the key role of CD90 + CD105 + endothelial cells in tumour heterogeneity and predicts disease recurrence.Experimental hematology & oncology · 2025Article
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2 authors.
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Abstract
backgroundPapillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with a generally favourable prognosis. However, a subset of PTC cases exhibit aggressive behaviour, including lymph node and distant organ metastases. Identifying biomarkers that can differentiate between benign and malignant lesions, as well as predict tumour aggressiveness, is crucial for improving diagnosis and management. CD105 (endoglin), a marker of neoangiogenesis, has shown promise in various solid tumours as a prognostic factor. Its role in PTC, particularly in distinguishing between metastatic and non-metastatic cases, remains underexplored.
aimsTo investigate the role of CD105 (endoglin) expression in the differential diagnosis and prognostic evaluation of patients with benign thyroid nodules, non-metastatic PTC, and PTC with lymph node metastasis (LNM).
methodsThyroid tissues from 148 patients were retrospectively analyzed for CD105 expression, including 49 with thyroid follicular nodular disease (TFND), 48 with PTC without LNM [LNM(-) PTC], and 51 with PTC and LNM [LNM(+) PTC]. Tissues were classified based on CD105 expression, and microvascular density (MVD) scores were calculated using the Weidner method in positive cases. Clinical and pathological features were compared across TFND, LNM(-), and LNM(+) groups.
resultsThe rates of CD105 expression significantly differed between the TFND, LNM(-) PTC, and LNM(+) PTC groups (8.2%, 64.6%, and 80.4%, respectively). The CD105 MVD score was significantly higher in the LNM(+) PTC, unifocal LNM(+) PTC, and multifocal LNM(+) PTC groups, in favour of metastasis (p < 0.001). CD105 expression was detected in all patients with distant organ metastasis, and these patients also exhibited significantly higher MVD scores (p < 0.001).
conclusionThis study supports the potential use of CD105 expression and its quantitative indicator, the CD105 MVD score, as biomarkers for distinguishing benign thyroid nodules from malignant ones and for evaluating the prognosis of PTC.
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