Evidence map›Paper›PMID 40485115›Full record

ArticleDevelopmental neurobiology2025

Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome-Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development.

Yvet Kroeze, Martin Oti, Roel H M Cooijmans, Ellen van Beusekom, Leonie I Kroeze, Anthonieke Middelman, Hans van Bokhoven, Sharon M Kolk, Judith R Homberg, Huiqing Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yvet KroezeDonders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Medical Neuroscience, Radboud University Medical Center, Nijmegen, Gelderland, the Netherlands.ORCID 0009-0002-2339-8237
Martin OtiDepartment of Molecular Developmental Biology, Faculty of Science, Radboud University, Radboud Institute for Molecular Life Sciences, Nijmegen, Gelderland, the Netherlands.
Roel H M CooijmansDepartment of Molecular Developmental Biology, Faculty of Science, Radboud University, Radboud Institute for Molecular Life Sciences, Nijmegen, Gelderland, the Netherlands.
Ellen van BeusekomDepartment of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Nijmegen, Gelderland, the Netherlands.
Leonie I KroezeDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, Gelderland, the Netherlands.
Anthonieke MiddelmanDonders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Medical Neuroscience, Radboud University Medical Center, Nijmegen, Gelderland, the Netherlands.
Hans van BokhovenDepartment of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Nijmegen, Gelderland, the Netherlands.
Sharon M KolkDonders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Molecular Animal Physiology, Radboud University, Nijmegen, Gelderland, the Netherlands.ORCID 0000-0003-2116-5456
Judith R HombergDonders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Medical Neuroscience, Radboud University Medical Center, Nijmegen, Gelderland, the Netherlands.ORCID 0000-0002-7621-1010
Huiqing ZhouDepartment of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Nijmegen, Gelderland, the Netherlands.ORCID 0000-0002-2434-3986

Funding

Donders Institute for Brain, Cognition, and BehaviourH2020 Marie Skłodowska-Curie Actions
6 · The paper itself

Abstract

Reduced expression of the serotonin transporter (5-hydroxytryptamine transporter, 5-HTT) in early life has been associated with a delay in postnatal brain development and endophenotypes of a variety of neuropsychiatric and neurodevelopmental disorders in adolescence and adulthood. How a reduction in functional 5-HTT can disrupt neurodevelopment is still largely unknown. Here, we studied genome-wide gene expression using transcriptome analysis (RNA-seq) and global levels of DNA (hydroxy)methylation (5(h)mC) using high-performance liquid chromatography-tandem mass spectrometry in 5-HTT wild-type (5-HTT

Indexed as

DNA MethylationGene Expression Regulation, DevelopmentalPrefrontal CortexSerotonin Plasma Membrane Transport ProteinsSynaptic TransmissionAnimalsAnimals, NewbornMaleRatsSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, ratdevelopmentprefrontal cortexratRNA‐seqserotonin transporter

Identifiers

PMID40485115
PMCPMC12146603

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.