ArticleMicrobial biotechnology2025
Chicken Manure as a Sustainable Bile Acid Source for Biotechnological Applications.
Article in Microbial biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The gut-liver axis in animal diseases: roles, mechanisms, and veterinary clinical applications.Frontiers in veterinary science · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
Ursodeoxycholic acid (UDCA) is widely administered to dissolve gallstones, treat liver disorders and reduce blood cholesterol levels. This study investigated fresh and dried chicken manure as a sustainable bioresource for chenodeoxycholic acid (CDCA), a precursor for the biotechnological production of UDCA. For this, bile acids from five commercial dried and seven fresh chicken manure samples were analysed. The bile acid pool consisted predominantly of CDCA (30%-90%) and 7-keto lithocholic acid (7k-LCA, 8%-56%), with minor amounts of cholic acid. CDCA concentrations varied between 62 and 2990 mg per kg dry weight, and the highest concentrations were found in two samples from fresh chicken manure, confirming that chickens can produce high but varying amounts of faecal CDCA. As a proof of principle, a newly created Pseudomonas putida KT2440 strain expressing a heterologous 7α-/7β-hydroxysteroid dehydrogenase system was shown to be able to transform manure-derived CDCA into UDCA without prior substrate purification from raw ethanolic chicken manure extracts. These results demonstrate that chicken manure can be used as an untapped resource for bile acids for biotechnological applications, providing a novel approach for the valorisation of this bioresource.
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Registered trials
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