Evidence map›Paper›PMID 40484953›Full record

ArticleBMC emergency medicine2025

Co-design of a Mobile Stroke Unit pathway highlights uncertainties and trade-offs for viable system-wide implementation in the English and Welsh NHS.

L Moseley, P McMeekin, M Allen, G A Ford, M James, A Laws, S McCarthy, G McClelland, L J Park, K Pearn and 6 more

Abstract read
In one paragraph

Article in BMC emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

L MoseleyFaculty of Health and Life Sciences, Northumbria University, Newcastle Upon Tyne, UK.
P McMeekinFaculty of Health and Life Sciences, Northumbria University, Newcastle Upon Tyne, UK.
M AllenUniversity of Exeter Medical School, Exeter, UK.
G A FordOxford University Hospitals NHS Foundation Trust, Oxford, UK.
M JamesUniversity of Exeter Medical School, Exeter, UK.
A LawsUniversity of Exeter Medical School, Exeter, UK.
S McCarthyFaculty of Health and Life Sciences, Northumbria University, Newcastle Upon Tyne, UK.
G McClellandFaculty of Health and Life Sciences, Northumbria University, Newcastle Upon Tyne, UK.
L J ParkFaculty of Health and Life Sciences, Northumbria University, Newcastle Upon Tyne, UK.
K PearnUniversity of Exeter Medical School, Exeter, UK.
D PhillipsEast of England Ambulance Service NHS Trust, Cambridgeshire, UK.
C PriceStroke Research Group, Population Health Sciences Institute / Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.
L ShawStroke Research Group, Population Health Sciences Institute / Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.
P WhiteStroke Research Group, Population Health Sciences Institute / Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.
D WilsonStroke Service User Voice Group, Newcastle Upon Tyne, UK.
J ScottFaculty of Health and Life Sciences, Northumbria University, Newcastle Upon Tyne, UK. Jason.scott@northumbria.ac.uk.

Funding

National Institute for Health and Care Research NIHR153982
6 · The paper itself

Abstract

backgroundMobile stroke units (MSUs) are specialist ambulances equipped with scanning and point of care testing that can identify patients eligible for intravenous thrombolysis - medication to dissolve a clot used in ischaemic strokes - and provide this on location. While benefits of MSUs have been demonstrated, this is context dependent. Routine use of MSUs across the English and Welsh National Health Service (NHS) has not yet been considered, and as such no pathway for their operation exists. This study aimed to co-design a viable pathway, detailing dispatch, staffing and treatment decisions, for MSUs within the NHS context.

methodsThe study used interdisciplinary co-design alongside Nominal Group Technique (NGT) to generate consensus. Participants were recruited using a combination of purposive, opportunistic and snowball sampling. Data collection took place in online workshops, across three rounds, with supplemental interviews conducted where required. Data were analysed as an ongoing process, with participants checking interpretations after each round, and then further analysed deductively to identify key uncertainties following all the rounds. Consensus threshold for the NGT was set a priori at ≥ 80%.

resultsAn MSU pathway that reached consensus for being viable within the NHS was developed with consideration for current systems and pressures. Key uncertainties were identified such as where to base the MSU. We also identified where participants had to make trade-offs in the co-designed pathway, such as staffing considerations. Together, the uncertainties and trade-offs represent challenges to MSU implementation and are presented alongside the process to reach the finalised pathway. Future developments which may have implications for the implementation of MSUs were also explored.

conclusionsThe co-designed MSU pathway provides a foundation for MSU implementation in the English and Welsh NHS and can be subjected to local and regional modifications required for implementation. However, optimal implementation is likely hindered by several uncertainties and trade-offs, including the geographical base of the MSU and staffing, that represent challenges to implementation of MSUs at scale. Future developments in acute stroke care may help to mitigate these challenges, such as developments in artificial intelligence to read scans and improved access to telemedicine. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

AmbulancesCritical PathwaysMobile Health UnitsStrokeEnglandHumansState MedicineThrombolytic TherapyUncertaintyWalesCo-productionEmergency medicineMobile stroke unitNominal group techniquePathway developmentPre-hospital careStroke

Identifiers

PMID40484953
PMCPMC12147245

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.