ArticleInfectious diseases of poverty2025
Global estimation of dengue disability weights based on clinical manifestations data.
Article in Infectious diseases of poverty, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Methods for estimating the burden of acute tropical infectious diseases: A scoping review.PLoS neglected tropical diseases · 2026Article
- Global, regional, and national temporal trend and patterns of change in the burden of leishmaniasis from 1990 to 2021: an analysis of the Global Burden of Disease Study 2021.Science in One Health · 2025Article
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Abstract
backgroundDengue is a major global health threat with varied clinical manifestations across age groups, countries, and regions. This study aims to estimate global dengue disability weights (DWs) based on clinical manifestations data and examine variations across different demographics and geographical areas. These findings will inform public health strategies and interventions to reduce the global burden of dengue.
methodsWe conducted a systematic search across six databases (Scopus, Web of Science, PubMed, China National Knowledge Infrastructure, Wanfang Data, and Database of Chinese sci-tech periodicals) for studies on human dengue clinical manifestations or infection from the establishment of each database through December 31, 2023. DWs were estimated by combining clinical manifestations frequencies with corresponding DW values derived from the Global Burden of Disease (GBD) study, using Monte Carlo simulations to generate uncertainty intervals. Odds ratios (ORs) with 95% confidence intervals (CI) and Chi-square tests were performed to compare clinical manifestations between adults and children.
resultsA total of 35 adult studies (7109 cases) and 17 pediatric studies (2996 cases) were analysed. Adults had higher rates of muscle pain (OR = 9.18; 95% CI: 8.17-10.33) and weak (OR = 4.95; 95% CI 4.12-5.98). Children showed higher frequencies of decreased appetite (OR = 0.12; 95% CI: 0.11-0.14) and lymphadenectasis (OR = 0.04; 95% CI: 0.03-0.06). Severe dengue was more prevalent in children (8.2%) than adults (4.6%). The global DW for universal dengue was 0.3258 in adults and 0.4022 in children, with Indian children showing the highest DW for severe dengue (0.6991) and Chinese adult showing the highest DW for severe dengue (0.7214). Regionally, most studies were from South and Southeast Asia, with India contributing the largest number of publications (80 articles). Additionally, India had the highest dengue disease burden in 2021 (352,468.54 person-years).
conclusionsThese findings reveal important age and regional differences in dengue disease burden. There is a relative lack of research on dengue clinical manifestations in several high-burden countries in the Americas, and these gaps may affect the comprehensiveness and accuracy of global dengue disability weight estimates. These highlight the urgent need for targeted interventions and optimized resource allocation to mitigate its global impact.
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