ArticleBMC women's health2025
HPV vaccination, screening disparities, and the shifting landscape of cervical cancer burden: a global analysis of trends, inequalities, and policy implications.
Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- HPV in breast cancer: prevalence and comparison with healthy tissue-a systematic review and meta-analysis.Cancer causes & control : CCC · 2026Pooled it
- Cervical cancer screening policy inequality worldwide: a systematic review of disparities in access and implementation.Journal of translational medicine · 2026Pooled it
- Geographic and temporal variations in cancer incidence attributable to human papillomavirus infection in China: a population-based study.BMC public health · 2026Article
- PARP1 genetic variants modulate gene expression and cervical cancer susceptibility in a North Indian case-control study.Molecular biology reports · 2026Article
- The Cervical Cancer Paradox in Eastern Europe: How Knowledge and Institutional Trust Shape HPV Vaccination Attitudes in Romania.Medical sciences (Basel, Switzerland) · 2026Observational
- Prevalence and genotype distribution of human papillomavirus (HPV) in Tehran, Iran: a retrospective cross sectional study (2011-2024).Virology journal · 2026Article
- Cost-Effectiveness of Nationwide HPV Vaccination in Girls in Kazakhstan: A UNIVAC-Based Analysis.Vaccines · 2026Article
- Observational
- The global burden of early-onset cancer in women, 1990-2021: findings from the GBD 2021 with focus on China.Journal of the National Cancer Center · 2026Article
- Global Comparative Review of Guidelines for Cervical Adenocarcinoma In Situ.Life (Basel, Switzerland) · 2026Review
- The role of E7 oncoprotein self-sampling and self-testing in cervical cancer screening.BMC women's health · 2026Article
- Integrative network pharmacology, molecular dynamics simulation, and single-cell RNA sequencing strategies reveal the multi-target mechanisms of oridonin against cervical cancer.Frontiers in pharmacology · 2026Article
- Is Moderately Hypofractionated Radiotherapy a Safe and Effective Strategy for Cervical Cancer?-A Review of Current Evidence.Current oncology (Toronto, Ont.) · 2026Review
- The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection.Ecancermedicalscience · 2026Review
- Current Perspectives on Human Papillomavirus (HPV): Strengthening the Evidence Base for Global Elimination.Biomedicines · 2025Article
- Hyaluronic Acid in Female Reproductive Health: Tailoring Molecular Weight to Clinical Needs in Obstetric and Gynecological Fields.Pharmaceutics · 2025Review
- Knowledge, attitudes, and barriers to cervical cancer screening utilization among female healthcare professionals in the Tamale Metropolis.Women's health (London, England)Article
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8 authors.
Funding
Abstract
synopsisHealth inequalities intensified, burden shifting to low-resource regions despite preventive advancements. HPV and screening rates diverged by SDI, highlighting coverage gaps. Screening and vaccination inversely linked to disease burden, underscoring critical efficacy. Innovative modeling exposed disparities, advocating SDI-stratified interventions.
objectiveThis study analyzes global and regional cervical cancer trends (1990-2021) across different Socio-Demographic Index (SDI) levels, highlighting health inequalities, assessing the impact of HPV vaccination and screening, and modeling future trends. The findings aim to inform targeted prevention policies, reduce regional disparities, and promote global health equity.
methodsData were sourced from the Global Burden of Disease study 2021(GBD 2021), OECD, and WHO. The focus was on incidence and disability-adjusted life years (DALYs) of cervical cancer. Time trends were analyzed by SDI regions, alongside health inequality assessments. Correlation analyses examined links between screening rates, HPV vaccination coverage, and disease burden.
resultsFrom 1990 to 2021, global age-standardized incidence rate and age-standardized DALYs rates declined significantly, with estimated annual percentage changes (EAPC) of -0.54% (95% CI: -0.63 to -0.44) and - 1.27% (95% CI: -1.36 to -1.18). However, significant differences exist in specific patterns of change across SDI regions: exhibited an upward incidence trajectory. From 1990 to 2021, the burden of cervical cancer disease shifted from developed to less developed regions. Correlation analysis showed negative associations between screening rates and DALYs (r = -0.56, p < 0.01) and between vaccination coverage and incidence (r = -0.35, p < 0.01).
conclusionAlthough the global cervical cancer burden has decreased, significant regional disparities remain. Future policies should focus on tailored interventions, with low-resource regions strengthening healthcare infrastructure and implementing minimum effective preventive measures, while high-SDI regions shift to precision public health approaches. Policymakers must also incorporate culturally sensitive health education to address social barriers, challenge misconceptions, and empower communities, ultimately reducing preventable cervical cancer morbidity.
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