Evidence map›Paper›PMID 40484929›Full record

ArticleBMC medicine2025

Longitudinal plasma amino acids during pregnancy and neonatal anthropometry: findings from the NICHD Fetal Growth Studies-Singleton Cohort.

Claire Guivarch, Jing Wu, Ruijin Lu, Jagteshwar Grewal, Guoqi Yu, Ling-Jun Li, Jiaxi Yang, Wei Wei Pang, Dong D Wang, Natalie L Weir and 3 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912132 (The National Standard for Normal Fetal Growth), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00912132 completednot on this map

The National Standard for Normal Fetal Growth

TypeobservationalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2009 to 2013Enrolled2,802ConditionsPregnancy, Fetal Growth
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Claire GuivarchGlobal Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jing WuGlotech Inc, Bethesda, MD, USA.
Ruijin LuInstitute for Informatics, Data Sciences & Biostatistics, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Jagteshwar GrewalDivision of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Guoqi YuGlobal Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ling-Jun LiGlobal Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jiaxi YangGlobal Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Wei Wei PangGlobal Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Dong D WangChanning Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital and Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Natalie L WeirDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Zhen ChenDivision of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Cuilin ZhangGlobal Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. obgzc@nus.edu.sg.

Funding

Towards Precision Nutrition for Alzheimer's Dementia Prevention: A Prospective Study of Dietary Patterns, the Gut Microbiome and Cognitive FunctionR01AG077489 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Dong Wang · 2022 to 2026
$4.4M
The Gut Microbiome and Personalized Mediterranean Diet Interventions for Cardiometabolic Disease PreventionR01NR019992 · NINR · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, DONG · 2021 to 2025
$3.8M
Mediterranean Diet, Polyphenol-Rich Foods, Gut Microbiota and Type 2 DiabetesR00DK119412 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, DONG · 2020 to 2022
$747k
Mediterranean Diet, Polyphenol-Rich Foods, Gut Microbiota and Type 2 DiabetesK99DK119412 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI WANG, DONG · 2018 to 2019
$181k
NIA NIH HHS R01 AG077489NIDDK NIH HHS K99 DK119412NIDDK NIH HHS R00 DK119412NINR NIH HHS R01 NR019992
6 · The paper itself

Abstract

backgroundAmino acids (AAs) during pregnancy are crucial for fetal growth. Prior studies measured AA concentrations at single time points in pregnancy, despite their fluctuations throughout pregnancy. We measured plasma AA profiles in blood samples longitudinally collected from early through late pregnancy and evaluated their associations with neonatal anthropometry.

methodsConcentrations of plasma aromatic AAs, branched-chain AAs, and AAs involved in one-carbon metabolism were assessed at 10-14, 15-26, 23-31, and 33-39 gestational weeks (GW) among 321 women from a case-control study from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singleton Cohort. Associations between AA concentrations in tertiles at each visit and neonatal anthropometric measures were assessed using weighted generalized estimating equations models, after adjusting for major confounders.

resultsWomen with higher concentrations of glutamine (3rd vs. 1st tertile) at 10-14 GW had offspring with greater birthweight z-score (β [95% CI] = 0.31 [0.06, 0.56], p-trend = 0.04) and birth length (1.35 cm [0.32, 2.37], p-trend = 0.04). Women with higher concentrations of aspartic acid (3rd vs. 1st tertile) at 23-31 GW, however, had offspring with smaller sum of skinfolds (- 3.9 mm [- 6.0, - 1.7], p-trend = 0.007). Similarly, women with higher concentrations of glycine (3rd vs. 1st tertile) at 10-14 GW had offspring with lower birthweight z-score (- 0.37 [- 0.65, - 0.08], p-trend = 0.04).

conclusionsPlasma AA concentrations during pregnancy appear to play a crucial role in neonatal anthropometry. Associations were observed as early as 10 GW and varied by type of AAs and gestational age.

trial registrationClinical Trial Registry number: NCT00912132.

Indexed as

Amino AcidsAnthropometryFetal DevelopmentAdultBirth WeightCase-Control StudiesCohort StudiesFemaleGestational AgeHumansInfant, NewbornLongitudinal StudiesNational Institute of Child Health and Human Development (U.S.)PregnancyUnited StatesYoung AdultAmino AcidsAmino acidsBirth lengthBirthweightNeonatal anthropometryPregnancySum of skinfolds

Identifiers

PMID40484929
PMCPMC12147351

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.