Interrogation of Interfering Factors in ELISA Detecting Angiotensin Receptor Antibodies and Specificity Validation Using the Adsorption Elution Crossmatch (AXE) Technique.

Adak Karamafrooz, Julie Nguyen, Hong Ma, Dave Lowe, Michael Trinh, Rui Pei, Robert Carroll

Abstract readValidation Study

In one paragraph

Article in HLA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Non-human leukocyte antigen antibodies in kidney transplantation: pathogenic mechanisms, detection methods, and clinical implications.Clinical transplantation and research · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adak KaramafroozR&D Biochemistry Department, One Lambda Inc., West Hills, California, USA.ORCID 0000-0002-6190-341X

Julie NguyenR&D Biochemistry Department, One Lambda Inc., West Hills, California, USA.

Hong MaR&D Biochemistry Department, One Lambda Inc., West Hills, California, USA.

Dave LoweR&D Biochemistry Department, One Lambda Inc., West Hills, California, USA.

Michael TrinhR&D Biochemistry Department, One Lambda Inc., West Hills, California, USA.

Rui PeiR&D Biochemistry Department, One Lambda Inc., West Hills, California, USA.

Robert CarrollDepartment of Health Sciences, University of South Australia, Adelaide, South Australia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate detection of HLAs and non-HLA antigens is critical for managing long-term allograft transplantation, particularly in the context of hyperacute, acute, and chronic allograft rejection. Recent studies have identified the role of non-HLA antibodies, such as those against Angiotensin II Type 1 receptor (AT

Indexed as

Graft RejectionHistocompatibility TestingIsoantibodiesReceptor, Angiotensin, Type 1AdsorptionAnimalsEnzyme-Linked Immunosorbent AssayHLA AntigensHumansKidney TransplantationSensitivity and SpecificitySerum Albumin, BovineHLA AntigensIsoantibodiesReceptor, Angiotensin, Type 1Serum Albumin, Bovine

Identifiers

PMID40484908

DOI10.1111/tan.70268

PMCPMC12146235

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.