Evidence map›Paper›PMID 40484885›Full record

ArticleAIDS and behavior2025

High Rates of Drug Use and Chemsex Among PrEP Users and People with HIV in Milan Highlight Need for Targeted Interventions.

Chiara Fusetti, Enrico Caruso, Andrea Giacomelli, Daniele Calzavara, Maria Vittoria Cossu, Nicoletta Frattini, Francesco Caruso, Pietro Vinti, Chiara Atzori, Francesco Petri and 4 more

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Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Chiara FusettiDepartment of Infectious Diseases, ASST FBF Sacco, Luigi Sacco University Hospital, Milan, Italy. fusetti.chiara@asst-fbf-sacco.it.ORCID http://orcid.org/0000-0002-1028-505X
Enrico CarusoMilano Checkpoint ETS, Milan, Italy.
Andrea GiacomelliDepartment of Infectious Diseases, ASST FBF Sacco, Luigi Sacco University Hospital, Milan, Italy.
Daniele CalzavaraMilano Checkpoint ETS, Milan, Italy.
Maria Vittoria CossuDepartment of Infectious Diseases, ASST FBF Sacco, Luigi Sacco University Hospital, Milan, Italy.
Nicoletta FrattiniMilano Checkpoint ETS, Milan, Italy.
Francesco CarusoDepartment of Infectious Diseases, ASST FBF Sacco, Luigi Sacco University Hospital, Milan, Italy.
Pietro VintiMilano Checkpoint ETS, Milan, Italy.
Chiara AtzoriDepartment of Infectious Diseases, ASST FBF Sacco, Luigi Sacco University Hospital, Milan, Italy.
Francesco PetriDepartment of Infectious Diseases, ASST FBF Sacco, Luigi Sacco University Hospital, Milan, Italy.
Spinello AntinoriDepartment of Infectious Diseases, ASST FBF Sacco, Luigi Sacco University Hospital, Milan, Italy.
Andrea GoriDepartment of Infectious Diseases, ASST FBF Sacco, Luigi Sacco University Hospital, Milan, Italy.
Massimo CernuschiMilano Checkpoint ETS, Milan, Italy.
Davide MoscheseDepartment of Infectious Diseases, ASST FBF Sacco, Luigi Sacco University Hospital, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemsex, the use of psychostimulant substances during sexual activity particularly among men who have sex with men (MSM), is a growing public health concern. This study aimed to assess drug use, engagement in chemsex, and related knowledge among pre-exposure prophylaxis (PrEP) users and people with HIV (PWH) attending two sexually transmitted infection (STI) services in Milan, Italy. An anonymous online survey was conducted between January and March 2024 at a hospital-based clinic and a community-based center. The questionnaire explored demographics, HIV/PrEP status, drug use, chemsex, its disclosure to healthcare providers, and perceptions of drug use trends. Among 420 respondents, of whom 365 (84%) PrEP-users and 55 (13%) PWH, 167 (40%) reported current drug use and 68 (16%) engaging in chemsex. Polydrug use was also common (96/167, 57%). Commonly used substances included cocaine (50/167, 30%), mephedrone (45/167, 27%), 3,4-methylenedioxymethamphetamine (36/167, 22%), gamma-hydroxybutyrate/gamma-butyrolactone (33/167, 20%) and ketamine (29/167, 17%). The use of methylenedioxypyrovalerone (25/167, 15%) and crystal methamphetamine (10/167, 6%) was also consistent. Of the drug users, 62 (37%) did not disclose their substance use to healthcare providers, frequently citing lack of inquiry by clinicians or the perception that disclosure was not relevant. A total of 223/420 (53%) respondents knew people who used substances, and of these, 90.6% (202) perceived an increase in substance use within their community. In conclusion, the study revealed high rates of drug use and chemsex in Milan underscoring the need for increased healthcare provider awareness, and stigma-free environments to support risk reduction for chemsex users.

Indexed as

Drug UsersHIV InfectionsHomosexuality, MalePre-Exposure ProphylaxisSexual BehaviorSubstance-Related DisordersAdultChemsexFemaleHealth Knowledge, Attitudes, PracticeHumansItalyMaleMiddle AgedSurveys and QuestionnairesYoung AdultChemsexDrug useHIVPrEPRisk reductionSurvey

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.