Evidence map›Paper›PMID 40484875›Full record

ArticleAdvanced healthcare materials2025

Effect of Nanoparticle Rigidity on the Interaction of Stromal Membrane Particles with Leukemia Cells.

Sander de Weerd, Xinyu Ma, Zahra Zohali, Lieve L Oudejans, Emmanouil Kyrloglou, Marc C A Stuart, Wouter H Roos, Jan Jacob Schuringa, Anna Salvati

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sander de WeerdNanomedicine and Drug Targeting, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands.
Xinyu MaNanomedicine and Drug Targeting, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands.
Zahra ZohaliNanomedicine and Drug Targeting, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands.
Lieve L OudejansDepartment of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, 9713 GZ, The Netherlands.
Emmanouil KyrloglouDepartment of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, 9713 GZ, The Netherlands.
Marc C A StuartElectron Microscopy, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 7, Groningen, 9747 AG, The Netherlands.
Wouter H RoosMolecular Biophysics, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 3, Groningen, 9747 AG, The Netherlands.
Jan Jacob SchuringaDepartment of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, 9713 GZ, The Netherlands.
Anna SalvatiNanomedicine and Drug Targeting, Groningen Research Institute of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands.ORCID https://orcid.org/0000-0002-9339-0161

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In acute myeloid leukemia (AML), disease relapse is often observed because of therapy-resistant leukemic stem cells that re-initiate the disease. Leukemic stem cells can tightly associate with mesenchymal stromal cells inside the bone marrow, which is considered to further drive drug resistance. Here, the cell membrane of bone marrow stromal cells is used to prepare cell membrane nanoparticles and study their interactions with AML cells. Cell membrane liposomes (CM-Liposomes) of different charge are prepared and either used directly, or after deposition on silica cores to modulate nanoparticle mechanical properties. Nanoparticle size, zeta potential and coating efficiency are analyzed by dynamic light scattering (DLS) and cryo electron microscopy (Cryo-EM) imaging. Atomic force microscopy (AFM) is used to characterize the mechanical properties of CM-Liposomes and confirm bilayer deposition on silica cores. Finally, uptake by leukemic cells is determined. No difference in uptake is found between soft CM-Liposomes and liposomes of the same composition without membrane components. Instead, after deposition on a rigid core, uptake is higher for the cell membrane particles. Preliminary results on primary cells from leukemia patients confirm this observation. These results show that nanoparticle rigidity strongly affects the interaction between cell membrane nanoparticles and the targeted cells.

Indexed as

Cell MembraneLeukemia, Myeloid, AcuteMesenchymal Stem CellsNanoparticlesCell Line, TumorHumansLiposomesSilicon DioxideLiposomesSilicon Dioxidecell membrane nanoparticlesleukemialipid‐coated nanoparticlesnanoparticle mechanical propertiesnanoparticle targeting

Identifiers

PMID40484875
PMCPMC12304856

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.