ArticleAdvanced healthcare materials2025
Engineering Anisotropic Mechanical Properties in Large-Scale Fabricated Cartilage Constructs Using Microfiber Reinforcement.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- A study on extracellular and cellular composition to advance towards the rational design of contractile human myocardium.Materials today. Bio · 2026Article
- Elastic scaffolds reinforced stem cell-laden collagen-derived hybrid hydrogels to engineer 3D anisotropic cellular microenvironment.Materials today. Bio · 2026Article
- Structural Guidance in 3D Microgel-in-Hydrogel Systems to Improve Chondrogenesis.Advanced healthcare materials · 2026Article
- DLP bioprinting of cartilage organoid-laden bioinks yields high-fidelity auricular constructs with enhanced chondrogenesis.Stem cell research & therapy · 2026Article
- From microtissues to macro solutions - The future of scalable and automated cartilage tissue engineering.Journal of orthopaedic translation · 2026Review
- Diels-Alder Click Chemistry as a Dynamic-Covalent Crosslinking Method in Spheroid-Encapsulating Hydrogels for Cartilage Engineering.Advanced healthcare materials · 2026Article
- Fibrillar Bundles as Fibrous Filler Materials for Attaining Cell Anisotropy in Bioprinting.Advanced healthcare materials · 2026Article
- Tissue maturation and development of mechanical properties in hyaluronic acid bioink-based cartilaginous constructs.Frontiers in bioengineering and biotechnology · 2026Article
- Engineering Anisotropic Mechanical Properties in Large-Scale Fabricated Cartilage Constructs Using Microfiber Reinforcement.Advanced healthcare materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Despite the growing prevalence of cartilage damage in the knee joint, effective regenerative treatments remain limited. One of the current challenges is the accurate matching of the local mechanical properties of the tissue, which vary throughout the articular joint surface. This study investigates the fabrication of cartilage constructs with anisotropic mechanical properties. Specifically, it aims to develop composite constructs by reinforcing gelatin-methacryloyl (gelMA) hydrogels with melt electrowritten (MEW) fibers arranged to mimic the surface anisotropic mechanical properties of the native articular cartilage. Large-size anisotropic MEW scaffolds are successfully generated, after which they are embedded in the hydrogel, yielding stable constructs. Local mechanical properties can be tailored by varying the fiber spacing while providing a suitable environment for Articular Cartilage Chondroprogenitor cells (ACPCs) to deposit a cartilage-like matrix. Importantly, unlike reinforcement with fibers generated with fused deposition modeling (FDM), reinforcement with MEW avoided stress shielding, thereby facilitating cell response. This highlights the potential of these reinforced constructs to further match local tissue characteristics and provide a durable solution for the restoration of larger cartilage defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.