Evidence map›Paper›PMID 40484356›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2025

Auditory and Visual Thalamocortical Connectivity Alterations in Unmedicated People With Schizophrenia: An Individualized Sensory Thalamic Localization and Resting-State Functional Connectivity Study.

John C Williams, Philip N Tubiolo, Roberto B Gil, Zu Jie Zheng, Eilon B Silver-Frankel, Natalka K Haubold, Sameera K Abeykoon, Dathy T Pham, Najate Ojeil, Kelly Bobchin and 6 more

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In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

John C WilliamsDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York; Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York; Medical Scientist Training Program, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York.
Philip N TubioloDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York; Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York; Scholars in BioMedical Sciences Training Program, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York.
Roberto B GilDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York-Presbyterian / Columbia University Irving Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York.
Zu Jie ZhengDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York; College of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, New York.
Eilon B Silver-FrankelDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York.
Natalka K HauboldDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York.
Sameera K AbeykoonDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York.
Dathy T PhamDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York; Department of Neurobiology and Behavior, Cornell University, Ithaca, New York.
Najate OjeilDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York-Presbyterian / Columbia University Irving Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York.
Kelly BobchinDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York.
Mark SlifsteinDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York-Presbyterian / Columbia University Irving Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York.
Jodi J WeinsteinDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York-Presbyterian / Columbia University Irving Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York.
Greg PerlmanDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York.
Guillermo HorgaDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York-Presbyterian / Columbia University Irving Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York.
Anissa Abi-DarghamDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York; Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York-Presbyterian / Columbia University Irving Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York; Department of Radiology, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York.
Jared X Van SnellenbergDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York; Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York-Presbyterian / Columbia University Irving Medical Center, New York, New York; New York State Psychiatric Institute, New York, New York; Department of Psychology, Stony Brook University, Stony Brook, New York. Electronic address: Jared.VanSnellenberg@stonybrookmedicine.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008444 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI FROHMAN, MICHAEL A. · 1992 to 2024
$12.6M
A data-driven reconceptualization of the RDoC construct of working memory: Neural correlates of underlying factors and implications for schizophreniaR01MH120293 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI VAN SNELLENBERG, JARED XAVIER · 2020 to 2024
$3.6M
Neurobiological correlates of auditory processing in health and disease: an RDoC studyR01MH109635 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI ABI-DARGHAM, ANISSA · 2016 to 2020
$3.5M
Towards an Integrated Understanding of Neurotransmitter Dysfunction in Schizophrenia: a Multimodal MRI StudyK23MH115291 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI WEINSTEIN, JODI JAY · 2018 to 2024
$1.2M
Translational Neuroscience of Functional Connectivity in SchizophreniaK01MH107763 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI VAN SNELLENBERG, JARED XAVIER · 2015 to 2019
$961k
Neural mechanisms of sensory predictions in schizophrenia with hallucinationsK23MH101637 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HORGA, GUILLERMO · 2014 to 2018
$862k
Scholars in BioMedical Sciences (SBMS) Training ProgramT32GM148331 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Styliani-Anna (Stella) E Tsirka · 2024 to 2026
$695k
Functional MRI in SchizophreniaR21MH126260 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DAI, WEIYING, HE, XIANG · 2022 to 2023
$467k
Mechanisms of impaired subcortical auditory processing in schizophreniaF30MH122136 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI WILLIAMS, JOHN CONNOR · 2019 to 2022
$180k
NIGMS NIH HHS T32 GM008444NIGMS NIH HHS T32 GM148331NIMH NIH HHS F30 MH122136NIMH NIH HHS K01 MH107763NIMH NIH HHS K23 MH101637NIMH NIH HHS K23 MH115291NIMH NIH HHS R01 MH109635NIMH NIH HHS R01 MH120293NIMH NIH HHS R21 MH126260
6 · The paper itself

Abstract

backgroundConverging evidence from clinical neuroimaging and animal models has strongly implicated dysfunction of thalamocortical circuits in the pathophysiology of schizophrenia (SZ). Preclinical models of genetic risk for SZ have shown reduced synaptic transmission from the auditory thalamus to the primary auditory cortex, which may represent a correlate of auditory disturbances such as hallucinations. However, human neuroimaging studies have found a generalized increase in resting-state functional connectivity (RSFC) between whole thalamus and sensorimotor cortex in people with SZ (PSZ). We aimed to more directly translate preclinical findings by specifically localizing auditory and visual thalamic nuclei in unmedicated PSZ and measuring RSFC to primary sensory cortices.

methodsIn this case-control study, 82 unmedicated PSZ and 55 matched healthy control participants (HCs) completed RSFC functional magnetic resonance imaging (fMRI) (N = 137). Auditory and visual thalamic nuclei were localized for 55 unmedicated PSZ and 46 HCs who also completed a sensory thalamic nuclei localizer fMRI task (n = 101). Using localized nuclei as RSFC seeds, we assessed group differences in auditory and visual thalamocortical connectivity and associations with positive symptom severity.

resultsAuditory thalamocortical connectivity was not significantly different between PSZ and HCs, but hyperconnectivity was associated with greater positive symptom severity in the bilateral superior temporal gyrus. Visual thalamocortical connectivity was significantly greater in PSZ relative to HCs in the secondary and higher-order visual cortex but was not predictive of positive symptom severity.

conclusionsThese results indicate that visual thalamocortical hyperconnectivity is a generalized marker of SZ, while hyperconnectivity in auditory thalamocortical circuits relates more specifically to positive symptom severity.

Indexed as

Auditory CortexConnectomeGeniculate BodiesSchizophreniaVisual CortexAdolescentAdultCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedYoung AdultFunctional localizationPositive symptomsResting-state functional connectivitySchizophreniaSensory processingThalamus

Identifiers

PMID40484356
PMCPMC12377521

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