Evidence map›Paper›PMID 40484338›Full record

ArticleEuropean journal of pharmacology2025

Combined effects of gabapentin with verapamil and metoprolol on cardiovascular function of anesthetized male rats.

Sarah Pribil Pardun, Spencer Duff, Ian Papenfus, Will Bruening, Yulong Li, Gurudutt Pendyala, Lie Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah Pribil PardunDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Spencer DuffDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Ian PapenfusDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Will BrueningDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yulong LiDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Gurudutt PendyalaDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Lie GaoDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address: lgao@unmc.edu.

Funding

Skeletal Muscle Nrf2: Exercise-Induced Cardiovascular ProtectionR01HL160820 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GAO, LIE · 2022 to 2025
$2.1M
NHLBI NIH HHS R01 HL160820
6 · The paper itself

Abstract

Gabapentin (GBP), at high plasma concentrations, negatively impacts cardiovascular function, causing bradycardia, hypotension, and impaired left ventricular (LV) function in rats. This study examines the combined effects of GBP with Verapamil (Ver) or Metoprolol (Met) on cardiovascular function in anesthetized male rats and its impact on Ca

Indexed as

GabapentinMetoprololVerapamilAnesthesiaAnimalsBlood PressureCell LineHeart RateMaleRatsRats, Sprague-DawleyGabapentinMetoprololVerapamilCardiovascular functionGabapentinMetoprololRatsVerapamil

Identifiers

PMID40484338
PMCPMC13251811

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.